一、个人简介
赵家军，山东第一医科大学附属省立医院主任医师、教授、博士生导师。内分泌糖脂代谢与脑老化教育部重点实验室主任，中华医学会内分泌学分会第十一届主任委员，国家杰出医师，国家名医（国之名医·卓越建树），山东省“泰山学者攀登计划”特聘专家。入选2024、2025年度全球前2%顶尖科学家榜单，2021、2023年进入中国工程院院士第二轮评审候选人名单。
二、研究方向
主要聚焦：糖尿病和甲状腺功能减退的“防”与“治”，实现关口前移、理论创新、体系建设。
三、团队成员
团队以赵家军教授为学术领军人，汇聚博士生导师17人、硕士生导师28人；国家自然科学基金杰出青年基金获得者、国家高层次青年人才计划入选者、国家百千万人才工程人选等国家级人才5人次，以及泰山学者攀登计划专家、泰山学者及青年专家等19人，研究方向覆盖临床医学、基础医学、药学、生物学、流行病学及人工智能等领域。团队成员在国家级及省级学会担任主委、副主委等核心职务，获国家科技进步二等奖2项，中国青年科技奖1项，中华医学科技奖2项，山东省科学技术最高奖1项，山东省科技奖一等奖7项、二等奖14项。科研立项225项，其中国家科技支撑计划、国家重点研发计划、国家自然科学基金重点项目等重大项目16项、国家优青等其他国家级项目76项。发表学术论文1000余篇，其中SCI收录500余篇。学术专著56部，组织制定及参编指南与专家共识66项。
建成了覆盖全国的内分泌代谢病临床诊疗和科研协同网络、智慧医疗、大数据、生物样本资源库、适宜技术推广、罕见病基因诊治等平台，构建了肥胖症、糖尿病、甲状腺等疾病的队列和早期防治体系，揭示了垂体激素调控脂代谢的分子机制，创立了“非经典垂体靶腺轴”新理论体系，开创了垂体激素调控机体代谢的新领域。
四、项目、获奖及荣誉情况概述
科技部国家科技支撑计划、国家重点研发计划首席科学家，第一完成人获国家科技进步奖二等奖2项，全国创新争先奖、何梁何利基金科学与技术进步奖、谈家桢临床医学奖、吴阶平-保罗.杨森医学药学奖、山东省科学技术最高奖。获批国家发明专利21项，转化4项，牵头制定中华医学会诊疗指南和专家共识19项，通讯（含共同）作者发表Cell、Nature、Cell Metabolism、Nature Metabolism、Cell Research期刊。
五、研究成果
1. Haiyan Zhou, Xu Feng, Jie Wen, Yao Xiao, Liwen Wang, Linyun Chen, Genqing Xie, Jiajun Zhao*, Yan Huang*, Xianghang Luo*. A skin-hypothalamus axis couples heat stress and metabolic dysfunction. Cell. 2026 Apr 21: S0092-8674(26)00346-6. doi: 10.1016/j.cell.2026.03.045.
2. Dalong Zhu#*, Jiajun Zhao#*, Hanqing Cai, Xuan Chu, Shuangling Xiu, Chengwei Song, Zhifeng Cheng, Hongyi Cao, Hongwei Jiang, Lili Zhang, Haifang Wang, Bimin Shi, Yanbing Li, Ming Liu, Bo Feng, Fengtai Xue, Huan Deng, Haoyu Li, Li Li, Yue Li, Qingyang Ma, Lei Qian* & the DREAMS-1 Investigators. Mazdutide versus placebo in Chinese adults with type 2 diabetes. Nature, 2025 Dec 17. doi: 10.1038/s41586-025-10026-w.
3. Qihang Li#, Yida Tang#, Xuefeng Yu#, Guijun Qin#, Limin Tian#, Lianjiang Cheng#, Yi Lu#, Zhigang Zhao#, Libin Liu#, Kai Zhang, Changjun Wang, Shuqing Zhang, Yong Xu, Guangyao Song, Fang Zhong, Xiude Fan, Zhixiang Wang, Yafei Wu, Yongfeng Song, Jiajun Zhao*, Thyroid function reference intervals by age, sex, and race: a cross-sectional study, Annals of Internal Medicine, 2025 Jul; 178(7):921-929
4. Tao Bo, Ling Gao, Zhenyu Yao, Shanshan Shao, Xuemin Wang, Christopher G. Proud*, Jiajun Zhao*. Hepatic selective insulin resistance at the intersection of insulin signaling and metabolic dysfunction-associated steatotic liver disease. Cell Metab. 2024 May 7;36(5):947-968.
5. Xiude Fan#, Yingzhou Shi#, Junming Han, Yongfeng Song*, Jiajun Zhao*. Beyond body weight: Diversified presentation of MASLD in lean, overweight, and obese participants. J Hepatol, 2024 Apr;80(4): e147-e150.
6. Xiude Fan#, Bofei Zhang#, Yingzhou Shi#, Luna Liu, Jiajun Zhao*. Systemic metabolic Abnormalities: Key drivers of complications and mortality in MASLD. J Hepatol. 2024 Feb 2: S0168-8278(24)00105-3.
7. Zhenyu Yao#, Ying Gong#, Wenbin Chen , Shanshan Shao,Yongfeng Song, Honglin Guo, Qihang Li, Sijin Liu,Ximing Wang, Zhenhai Zhang, Qian Wang, Yunyun Xu,Yingjie Wu, Qiang Wan, Xinya Zhao, Qiuhui Xuan, Dawei Wang,Xiaoyan Lin , Jiawen Xu, Jun Liu, Christopher G. Proud, Xuemin Wang,Rui Yang, Lili Fu, Shaona Niu, Junjie Kong, Ling Gao*,Tao Bo*, Jiajun Zhao*, Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice. Nat Metab, 2023 Oct;5(10):1706-1725.
8. Xiude Fan#, Junming Han#, Enfa Zhao, Jiansong Fang, Dawei Wang, Yiping Cheng, Yingzhou Shi, Zhen Wang, Zhenyu Yao, Peng Lu, Tianbao Liu, Qihang Li, Kyle L Poulsen, Zhongshang Yuan, Yongfeng Song*, Jiajun Zhao*, The Effects of Obesity and Metabolic Abnormalities on Severe COVID-19- related Outcomes after Vaccination: A Population-Based Study, Cell Metab, 2023 Apr 4;35(4):585-600.
9. Yongfeng Song#, Junjun Liu#, Ke Zhao#, Ling Gao, Jiajun Zhao*, Cholesterol-induced toxicity: an integrated view of the role of cholesterol in multiple diseases, Cell Metab, 2021, Oct 5,33(10):1911-1925.
10. Yanjing Guo, Meng Zhao, Tao Bo, Shizhan Ma, Zhongshang Yuan, Wenbin Chen, Zhao He, Xu Hou, Jun Liu, Zhenhai Zhang, Qiang Zhu, Qiangxiu Wang, Xiaoyan Lin, Zhongli Yang, Min Cui, Lu Liu, Yujie Li, Chunxiao Yu, Xiaoyi Qi, Qian Wang, Haiqing Zhang, Qingbo Guan, Lifang Zhao, Shimeng Xuan, Huili Yan, Yanliang Lin, Li Wang, Qihang Li, Yongfeng Song*, Ling Gao*, Jiajun Zhao*, Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol, Cell Res, 2019, Feb, 29(2): 151-166.
