一、个人简介

谢玮，教授，博士生导师，山东省泰山学者青年专家。2014年于厦门大学获得细胞生物学博士学位；2015年至2016年在山东大学药学院进行博士后研究工作；2016年至2022年在山东师范大学生命科学学院工作；2023年任职于山东第一医科大学医学科技创新中心。

二、研究领域

细胞连接结构的异常不仅直接损害表皮屏障功能，更可通过暴露隐蔽抗原表位（如DSG3构象表位、BP180胞外域剪切片段）触发免疫级联反应，推动天疱疮、大疱性类天疱疮及银屑病等疾病的发生。课题组以细胞模型、基因工程动物及临床患者样本为研究工具，系统探索细胞间连接完整性与自身免疫性及炎症性皮肤疾病发生发展的关联机制。

三、项目、获奖及荣誉情况概述

先后承担国家自然科学基金面上项目、国家自然科学基金青年科学基金项目、山东省自然科学基金面上项目等。相关研究发表在Cell Reports、Signal Transduction and Targeted Therapy、Autophagy、Journal of Biological Chemistry、Journal of Genetics and Genomics、Journal of Cellular Physiology等国际主流期刊。

四、代表性研究成果

1. Xie, Wei#, Gao, Siqi#, Yang, Yunfan*, Li, Hongjie, Zhou, Junyan, Chen, Mingzhen, Yang, Song, Zhang, Yijun, Zhang, Liang, Meng, Xiaoqian, Xie, Songbo, Liu, Min, Li, Dengwen, Chen, Yan, and Zhou, Jun* (2022). CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart. Cell Reports, 41, 111864. 10.1016/j.celrep.2022.111864. (IF: 9.995)

1. Liu, Yuanyuan, Yan, Shaoze, Wang, Jiaxuan, Dong, Dan, Yan, Shaodong, Yin, Hanxiao, Liu, Kai, Liu, Min, Liu, Hong, Li, Dengwen, Gao, Jinmin, Xie, Wei*, Zhou, Jun* (2026). The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis. Cel Death & Differentiation, (中科院一区 TOP 期刊，五年影响因子13.7)

2. Xie, Wei#, Gao, Siqi#, Yang, Yunfan*, Li, Hongjie, Zhou, Junyan, Chen, Mingzhen, Yang, Song, Zhang, Yijun, Zhang, Liang, Meng, Xiaoqian, Xie, Songbo, Liu, Min, Li, Dengwen, Chen, Yan, and Zhou, Jun* (2022). CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart. Cell Reports, 41, 111864. 10.1016/j.celrep.2022.111864. (中科院一区 TOP期刊，五年影响因子8.1)

3. Xie, Wei, Chen, Mingzhen, Zhai, Zhaodong, Li, Hongjie, Song, Ting, Zhu, Yigao, Dong, Dan, Zhou, Peng, Duan, Liangwei, Zhang, You, Li, Dengwen, Liu, Xinqi, Zhou, Jun, and Liu, Min* (2021). HIV-1 exposure promotes PKG1-mediated phosphorylation and degradation of stathmin to increase epithelial barrier permeability. Journal of Biological Chemistry 296, 100644. 10.1016/j.jbc.2021.100644. (中科院

二区期刊/自然指数期刊，五年影响因子4.3)

4. Xie, Wei, Li, Dengwen*, Dong, Dan, Li, Yuanyuan, Zhang, You, Duan, Liangwei, Liu, Xinqi, Meng, Wenxiang, Liu, Min, and Zhou, Jun* (2020). HIV-1 exposure triggers autophagic degradation of stathmin and hyperstabilization of microtubules to disrupt epithelial cell junctions. Signal Transduction and Targeted Therapy 5, 79. 10.1038/s41392-020-0175-1. (中科院一区 TOP期刊，五年影响因子52.2)

5. Xie, Wei#, Yang, Yunfan#, Gao, Siqi, Song, Ting, Wu, Yuhan, Li, Dengwen, Liu, Min, and Zhou, Jun* (2017). The tumor suppressor CYLD controls epithelial morphogenesis and homeostasis by regulating mitotic spindle behavior and adherens junction assembly. Journal of Genetics and Genomics 44, 343-353. 10.1016/j.jgg.2017.06.002. (中科院一区 TOP 期刊，五年影响因子6.4)

6. Xie, Wei, Zhang, Lei, Jiao, Haifeng, Guan, Li, Zha, Junmin, Li, Xiaotong, Wu, Mian, Wang, Zhanxiang, Han, Jiahuai, and You, Han* (2015). Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy 11, 1623-1635. 10.1080/15548627.2015.1075688. (中科院一区 TOP 期刊，五年影响因子17.1)

五、联系方式

课题组长期招收研究生和博士后，欢迎加盟！

地址：医学科技创新中心D311；邮箱：xiew@sdfmu.edu.cn