一、个人简介
副教授,硕士生导师,中西医结合博士生导师,泰山学者青年专家。中国医药生物技术协会药物分析技术分会青年委员,中国中医药信息学会中医临床药学分会委员,中国中医药研究促进会免疫疾病分会委员。2021年博士毕业于山东大学药学院,期间于美国辛辛那提大学交流访学。2021年9月全职引进山东第一医科大学生命科学学院/医学科技创新中心。主要研究方向为超分辨成像药物分析新方法、药物防治骨代谢病研究。
二、研究方向
1. 骨代谢病机制研究及新药发现
2. 超分辨成像药物分析新方法研究
三、项目、获奖及荣誉情况概述
主持国家自然科学基金1项,省自然等项目5项;以第一/通讯作者(含共)发表SCI论文10余篇,包括Advanced Drug Delivery Reviews、Advanced Science、Small Methods、Theranostics等国际学术期刊,影响因子10分以上8篇;授权中国发明专利2项。
(一)主持项目:
1. 国家自然科学基金青年基金,82302743,2024.01-2026.12,主持
2. 山东省自然科学基金青年基金,ZR2022QH304,2023.01-2025.12,主持
3. 国家中医药管理局-山东省卫健委共建中医药科技项目,GZY-KJS-SD-2023-085,2023.12-2026.11,主持
4. 山东省中医药科技项目,Q-2023059,2023.08-2025.07,主持
5. 山东省医药卫生科技项目,202404070376,2024.07-2026.06,主持
6. 泰山学者青年专家,tsqn202408252,2025.01-2027.12
(二)主要获奖情况:
1. 山东省医学科技奖
2. 山东省药学会科技奖
四、研究成果
1. Yongchun Wei, Jiaqi Xing, Jiarao Sun, Wei Chen, Gongchang Yu, Bin Shi*, Xintian Shao*, Yanfeng Wang* . Tumor microenvironment-based smart beacon drug delivery system for in situ visualization of tumor therapy. Chemical Engineering Journal. 2024, 500, 156923.
2. Daili Liu#, Guiqian Fang#, Yanfeng Wang, Caicai Meng, Qixin Chen*, Zhidong Liu*, Xintian Shao*. Facile Construction of Dual-response Super-resolution Probes for Tracking Organelles Dynamics. Exploration, 2024, 20230145.
3. Xintian Shao, Caicai Meng, Wenjing Song, Tao Zhang, Qixin Chen*. Subcellular visualization: Organelle-specific targeted drug delivery and discovery. Advanced Drug Delivery Reviews, 2023, 199, 114977.
4. Guiqian Fang, Huimin Chen, Xintian Shao,* Han Wang, Dongxue Zhan, Ran Wang, Peng Meng, Hongbao Fang, Fei Liu, Peixue Ling, Zhongyu Wu, Jiajie Diao, Qingqiang Yao,* and Qixin Chen*. Single Image Capture of Bioactive Ion Crosstalk within Inter-Organelle Membrane Contacts at Nanometer Resolution. Small Methods. 2022, 6, 200321.
5. Jiarao Sun, Xiaoli Cao, Wenjuan Lu, Yongchun Wei, Lingxiu Kong, Wei Chen, Xintian Shao*, Yanfeng Wang*. Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications. Theranostics. 2023, 13(5): 1716-1744.
6. Xintian Shao#, Zhou Fang#, Miaoling Li#, Weiwei Zou, Qianchun Wang, Chengying Zhang, Yongchun Wei, Zhiqi Tian, Yongchao Lai, Yunxia Cao, Baohua Ji, Dechang Li, Qixin Chen, and Jiajie Diao. Graphene Oxide Nanosheets Induce Mitochondrial Fragmentation by Cutting through Membrane. ACS Materials Letters. 2023, 5, 2308-2316.
7. Kang-Nan Wang# , Xintian Shao# , Zhiqi Tian# , Liu-Yi Liu# , Chengying Zhang#, Cai-Ping Tan, Jie Zhang, Peixue Ling, Fei Liu, Qixin Chen*, Jiajie Diao*, Zong-Wan Mao*.A continuous add-on probe reveals the nonlinear enlargement of mitochondria in light-activated oncosis. Advanced Science. 2021, 202004566.
8. Xintian Shao#, Qixin Chen#, Lianting Hu#, Zhiqi Tian, Liuyi Liu, Fei Liu, Fengshan Wang, Peixue Ling*, Zong-Wan Ma*, Jiajie Diao*. Super-resolution quantification of nanoscale damage to mitochondria in live cells. Nano Research, 2020, 13, 2149-2155.
9. Xintian Shao, Qixin Chen, Xixi Dou, Lei Chen, Jixu Wu, Wei Zhang, Huarong Shao, Peixue Ling*, Fei Liu*, Fengshan Wang*. Lower range of molecular weight of xanthan gum inhibits cartilage matrix destruction via intrinsic bax-mitochondria cytochrome c-caspase pathway. Carbohydrate Polymers, 2018, 198: 354-363.
五、联系方式
邮箱:shaoxintian@sdfmu.edu.cn
硕士招生专业:生物医药、生物学类;课题组长期招收博士后,欢迎相关领域的博士生加入本课题组开展科研工作!