董自亮 /     

研​究员

博士,硕士生导师,校(院)拔尖人才

一、个人简介

研究员,科创中心拔尖人才,2010年至2020年于苏州大学获得学士、硕士和博士学位(导师:刘庄教授),2020年至2022年在上海交通大学医学院分子医学研究院从事博士后研究(合作导师:谭蔚泓院士),2023年1月任职于山东第一医科大学医学科技创新中心。

二、研究方向

主要研究方向为功能生物材料的可控制备及在肿瘤微环境调控与诊疗中的应用。

三、项目、获奖及荣誉情况概述

在国际学术期刊共发表SCI论文90余篇,论文总引用11000余次,“H-index”55,其中,以第一作者(含共一)在Chem,J. Am. Chem. Soc.,Adv. Mater.,Nano Lett.,ACS Nano,Biomaterials等国际知名学术期刊上发表论文12篇,ESI高被引论文4篇。2021-2022年连续两年入选美国科睿唯安公布的“全球高被引科学家”(Highly Cited Researchers)名单(交叉学科);先后获得博士研究生国家奖学金,江苏省优秀博士学位论文,2021年度上海“超级博士后”激励计划,上海交通大学医学院“博士后激励计划”,中国博士后科学基金第70批面上一等资助等。

四、研究成果

[1] Z. Dong, L. Feng, Y. Hao, Q. Li, M. Chen, Z. Yang, H. Zhao, Z. Liu, Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress, Chem, 2020, 11, 1391-1407. (IF: 25.832)(高被引论文)

[2] Z. Dong, L. Feng, Y. Hao, M. Chen, M. Gao, Y. Chao, H. Zhao, W. Zhu, J. Liu, C. Liang, Q. Zhang, Z. Liu, Synthesis of Hollow Biomineralized CaCO3-Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity, Journal of the American Chemical Society, 2018, 140, 2165-2178. (IF: 16.383)(高被引论文)

[3] C. Wang#, Z. Dong# (Equal Contribution), Y. Hao, Y. Zhu, J. Ni, Q. Li, B. Liu, Y. Han, Z. Yang, J. Wan, Z. Liu, L. Feng, Coordination Polymer-Coated CaCO3 Reinforces Radiotherapy by Reprogramming the Immunosuppressive Metabolic Microenvironment, Advanced Materials, 2022, 34, 2106520. (IF: 32.086)

[4] Z. Dong, C. Wang, Y. Gong, Y. Zhang, Q. Fan, Y. Hao, Q. Li, Y. Wu, X. Zhong, K. Yang, L. Feng, Z. Liu, Chemical Modulation of Glucose Metabolism with a Fluorinated CaCO3 Nanoregulator Can Potentiate Radiotherapy by Programming Antitumor Immunity, ACS Nano, 2022, 16(9), 13884-13899. (IF: 18.027)

[5] Z. Dong, L. Feng, Y. Chao, Y. Hao, M. Chen, F. Gong, X. Han, R. Zhang, L. Cheng, Z. Liu, Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy, Nano Letters, 2019, 19, 805-815. (IF: 12.262) (高被引论文)

[6] R. Shi#; Z. Dong# (Equal Contribution), C. Ma, R. Wu, R. Lv, S. Liu, Y. Ren, Z. Liu, H. Mei, H. Busscher, J. Liu, High-yield, magnetic harvesting of extracellular outer-membrane vesicles from E. coli, Small, 2022, 18(48), 2204350. (IF: 15.153)

[7] Z. Dong, L. Feng, W. Zhu, X. Sun, M. Gao, H. Zhao, Y. Chao, Z. Liu, CaCO3 nanoparticles as an ultra-sensitive tumor-pH-responsive nanoplatform enabling real-time drug release monitoring and cancer combination therapy, Biomaterials, 2016,110, 60-70. (IF: 15.304)

[8] Z. Dong, H. Gong, M. Gao, W. Zhu, X. Sun, L. Feng, T. Fu, Y. Li, Z. Liu, Polydopamine nanoparticles as a versatile molecular loading platform to enable imaging-guided cancer combination therapy, Theranostics, 2016, 6, 1031. (IF: 11.6)(高被引论文)

[9] Z. Dong, Y. Hao, Q. Li, Z. Yang, Y. Zhu, Z. Liu, L. Feng, Metal-polyphenol-network coated CaCO3 as pH-responsive nanocarriers to enable effective intratumoral penetration and reversal of multidrug resistance for augmented cancer treatments, Nano Research, 2020,13, 3057-3067. (IF: 10.269)

[10] L. Feng#, Z. Dong# (Equal Contribution), C. Liang, M. Chen, D. Tao, L. Cheng, K. Yang, Z. Liu, Iridium nanocrystals encapsulated liposomes as near-infrared light controllable nanozymes for enhanced cancer radiotherapy, Biomaterials, 2018, 181 81-91. (IF: 15.304)

[11] Y. Han#, Z. Dong# (Equal Contribution), C. Wang, Q. Li, Y. Z, Yang. W. Zhu, Y. Zhang, Z. Liu, L. Feng, Ferrous Ions Doped Calcium Carbonate Nanoparticles Potentiate Chemotherapy by Inducing ferroptosis. Journal of Controlled Release, 2022, 348, 346-356. (IF: 11.467)

[12] Z. Dong, Z. Yang, Y. Hao, L. Feng, Fabrication of H2O2-driven nanoreactors for innovative cancer treatments, Nanoscale, 2019,11, 16164-16186. (IF: 8.307)

五、联系方式

课题组长期招收科研助理、研究生、博士后,同时欢迎优秀本科生提前加入课题组开展科研工作! 联系方式:zldong0220@163.com

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