一、个人简介

 山东第一医科大学教授，博导，山东省优青，泰山学者青年专家，主要从事分子影像与医工交叉方面的基础研究工作，以第一/通讯作者在Cell, ACS Nano (5篇), Advanced Functional Materials (4篇), Bioactive Materials (3篇), Advanced Science (2篇), Coordination Chemistry Reviews (2篇)，Biomaterials (2篇)等国际权威杂志发表系列SCI论文（IF>10论文36篇），总IF>600；主持国自然面上项目等3项国家级项目、7项省部级项目，授权国家发明专利17项；获山东省教学成果奖一等奖、山东省科技进步二等奖、于金明科技创新奖、英国皇家化学会生物材料科学“新锐科学家”，获校“优秀教师”、“优秀党员”、教工党支部书记“双带头人”等荣誉称号；现为BMEMat等多个杂志青年编委及Science Advances等杂志审稿人。

二、研究方向

医学影像探针、纳米药物、生物医用材料等。

三、团队成员

	代晓辉，山东第一医科大学副教授，博士毕业于山东大学，主要从事纳米合成与疾病治疗方面的基础研究工作，以第一作者在Advanced Science，Small，Chemical Engineering Journal，Nano Research，Journal of Hazardous Materials，Applied Catalysis A，General等国际权威杂志发表系列SCI论文多篇；授权国家发明专利2项；主持山东省及泰安市项目三项；获山东省材料科技奖一等奖、中国博士后创新创业大赛铜奖。
	张萌萌，博士毕业于山东大学，山东第一医科大学博士后，长期致力于医学影像与疾病诊疗相关研究。以第一作者发表Advanced Science，Small，ACS Applied Materials & Interfaces，SCI期刊论文6篇，主持国家自然科学基金青年项目、山东省自然科学基金青年项目、中国博士后面上项目，授权国家发明专利2项，获山东省材料科技奖一等奖、博士后创新创业大赛铜奖。
	NI NENGYI（倪能意），新加坡籍，本科及博士毕业于新加坡国立大学化学与生物分子工程专业（2026 QS排名3），并在DavidLeong教授（NanoEL技术创始人）团队从事了长达五年的研究，在此领域积累了扎实的基础和实践经验。主要研究方向为纳米材料诱导的多类型血管内皮渗漏现象与应用。目前，以第一作者（含共一）在Nature Communications, Advanced Science, Advanced Functional Materials, Biomaterials 等国际权威SCI期刊发表关于内皮渗漏和相关的论文，总IF > 160。

四、项目、获奖及荣誉情况概述

1、国家外专项目，2025.01-2026.12，主持

2、国家自然科学基金面上项目，2024.01-2027.12，主持

3、国家自然科学基金青年项目，2022.01-2024.12，主持

4、泰山学者青年专家项目，2025.1-2027.12，主持

5、山东省优青项目，2022.05-2025.04，主持

6、山东省高校青创科技计划，2022.01-2024.12，主持

7、山东省自然科学基金青年项目，2022.01-2024.12，主持

8、齐鲁卫生与健康杰出人才培育工程，2021.01-2025.12，主持

9、山东省海外科技人才项目，2022.01-2024.12，主持

五、研究成果

1. Y. Gao, M. Mu, Y. Wei, B. Yan, H. Liu, K. Guo, M. Zhang, X. Dai, X. Sun*, D.T. Leong*. Novel Ultrathin Ferrous Sulfide Nanosheets: Towards Replacing Black Phosphorus in Anticancer Nanotheranostics. Bioactive Materials, 2025, 43, 564-578. (IF=18.9)

2. X. Zhang, H. Liu, C. Wang, Y. Gao, S. Zhao, M. Mu, K. Ren, Y. Gong, Q. Fan*, X. Sun*. Dimeric PD-L1 Specific Affibody Grafted Fe-Based Nanosheets for Tumor-Targeting Dual-Mode Magnet Resonance Imaging and Enhancement of Photothermal-Immunotherapy. Chemical Engineering Journal, 2025, 159400. (IF=15.1)

3. Kai Guo, Hui Liu, Mengmeng Zhang, Nengyi Ni, Mengyao Mu, Ke Ren, Jiahui Chen, Qing Fan, Xueli Xu, Xiao Sun*, Ximing Wang*. Overcoming radiation-induced PD-L1 upregulation by novel gadolinium-palladium nanoplatforms for enhanced tumor radio-immunotherapy. Chemical Engineering Journal, 2025, 504, 158754. (IF=15.1)

4. J. Cui#, G. Wang#, L. X. Yip#, M. Dong, M. Mu, L. Tian, Y. Gao, Q. Fan, Q. Zhu, X. Zhao*, X. Xu*, D. T. Leong*, X. Sun*. Enhanced ferritin-manganese interaction by nanoplatinum growth enabling liver fibrosis three-dimensional magnetic resonance visualization and synergistic therapy with real-time monitoring. Advanced Functional Materials, 2024, 2410748. (IF=19)

5. H. Liu, M. Mu, Y. Hou, Y. Gong, C. Wang, G. Ma, K. Guo, L. Ma*, X. Sun*. A Novel Encapsulated Biomimetic Manganese Sulfide Nanourchins for Targeted Magnetic Resonance Contrast Enhancement and Self-Enhanced Chemodynamics-Gene-Immune Synergistic Tumor Therapy. Advanced Functional Materials, 2024, 2401370. (IF=19)

6. G. Ma#, X. Zhang#, K. Zhao#, S. Zhang, K. Ren, M. Mu, C. Wang, X. Wang, H. Liu*, J. Dong*, X. Sun*. Polydopamine nanostructure-enhanced water interaction with pH-responsive manganese sulfide nanoclusters for tumor magnetic resonance contrast enhancement and synergistic ferroptosis-photothermal therapy. ACS Nano, 2024, 18, 4, 3369-3381. (IF=17.1)

7. H. Liu, X. Dai, N. Li, L. Zhang, Z. Wang, K. Ren, Y. Li,* X. Sun,* J. Wan*. Injectable Magnetic Hydrogel Incorporated with Anti-inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis. Advanced Science, 2024, 2409778. (IF=14.3)

8. M. Mu , M. Zhang, Y. Gong, K. Guo, H. Liu, Z. Zhang, T. Jiang, H. Zhou, Q. Fan, D. Jia*, Y. Li*, X. Sun*, A multifunctional nanoplatform capable of dual action on tumor PD-L1 for  enhanced cancer theranostics. Chemical Engineering Journal, 2024, 502, 158139. (IF=15.1)

9. C. Wang, W. Tian, X. Dai, J. Yuan, N. Ni, Q. Fan, H. Liu, H. Sun*, J. Wan*, X. Sun*. Calcium ascorbate loaded ultrathin ferrous sulfide nanosheets thermo-sensitive hydrogels for near-infrared light activation of synergistic endometriosis therapy. Chemical Engineering Journal, 2024, 496, 153740. (IF=15.1)

10. S. Liu#, L. Tian#, M. Mu, Z. Liu, M. Dong, Y. Gong, X. Wang, Q. Meng*, H. Zhang*, X. Sun*. Platinum Nanoparticles-Enhanced Ferritin-Mn2+ Interaction for Magnetic Resonance Contrast Enhancement and Efficient Tumor Photothermal Therapy, Advanced Healthcare Materials, 2024, 2303939. (IF=10)

11. Y. Gong#, K. Guo#, S. Cai, K. Ren, L. Tian, Y. Wang, M. Mu, Q. Meng*, J. Liu*, X. Sun*. Customized Sized Manganese Sulfide Nanospheres as Efficient T1 MRI Contrast Agents for Enhanced Tumor Theranostics. Biomaterials Research, 2024, 28, 0116. (IF=11.6)

12. X. Xu, S. Xu, J. Wan, D. Wang, X. Pang, Y. Gao, N. Ni, D. Chen*, X. Sun*. Disturbing Cytoskeleton by Engineered Nanomaterials for Enhanced Cancer Therapeutics. Bioactive Materials, 2023, 29, 50-71. (IF=18.9)

1) X. Zhang, X. Xu, H. Liu, N. Ni, S. Liu, Y. Gong, G. Ma, L. Song, Q. Fan*, Q. Meng*, X. Sun*. CCR2-overexpressing Biomimetic Carrier-free Nanoplatform for Enhanced Cascade Ferroptosis Tumor Therapy. Acta Biomaterialia, 2023, 166, 604-614. (IF=10.6)

13. X. Zhang#, H. Ge#, Y. Ma, L. Song, Y. Ma, G. Tian, L. Wang, Q. Meng*, X. Sun*. Engineered anti-cancer nanomedicine for synergistic ferroptosis-immunotherapy. Chemical Engineering Journal, 2023, 455, 140688. (IF=15.1)

14. Y. Gao#, S. Liu#, H. Liu#, H. Ge, M. Zhang, C. Zhao, Y. Gong, X. Zhang, C. Wang*, X. Sun*, Z. Wu*. Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine. Science China Chemistry, 2023, 66, 2492-2512. (IF=10.1)

15. X. Xu, A. Liu, S. Liu, Y. Ma, X. Zhang, M. Zhang, J. Zhao, S. Sun, X. Sun*. Application of Molecular Dynamics Simulation in Self-assembled Cancer Nanomedicine. Biomaterials Research, 2023, 27, 39. (IF=11.6)

16. W. Tian, C. Wang, R. Chu, H. Ge, X. Sun*, M. Li*. Injectable hydrogel nanoarchitectonics with near-infrared controlled drug delivery for in situ photothermal/endocrine synergistic therapy. Biomaterials Research, 2023, 27, 100. (IF=11.6)

17. S. Xu#, X. Pang#, X. Zhang, Q. Lv, M. Zhang, J. Wang, N. Ni, X. Sun*. Nanomaterials disrupting cell-cell junctions towards various diseases. Nano Research, 2023, 16, 7053–7074. (IF=10.2)

18. N. Ni#, X. Zhang#, Y. Ma, J. Yuan, D. Wang, G. Ma, J. Dong*, X. Sun*. Biodegradable two-dimensional nanomaterials for cancer theranostics. Coordination Chemistry Reviews, 2022, 458, 214415. (IF=24.833)

19. J. Liu#, M. Huang#, X. Zhang#, Z. Hua, Z. Feng, Y. Dong, T. Sun*, X. Sun*, C. Chen*. Polyoxometalate nanomaterials for enhanced reactive oxygen species theranostics. Coordination Chemistry Reviews, 2022, 472, 214785. (IF=24.833)

20. H. Zhang#, M. Zhang#, X. Zhang, Y. Gao, Y. Ma, H. Chen, J. Wan, C. Li, F. Wang*, X. Sun*. Enhanced postoperative cancer therapy by iron-based hydrogels. Biomaterials Research, 2022, 26, 19. (IF=11.6)

21. N. Ni, W. Wang, Y. Sun, X. Sun*, D. T. Leong*. Inducible endothelial leakiness in nanotherapeutic applications. Biomaterials, 2022, 287, 121640. (IF=15.3)

六、联系方式

办公电话：15064071363

电子邮箱：chebiosx@126.com

主要办公地址：山东省济南市槐荫区青岛路山东第一医科大学，邮编：250000