一、个人简介

男，山东省优青，山东省创新团队带头人，齐鲁卫生与健康杰出青年人才，山东省海外科技人才，博导，博士后导师。曾在中国科学技术大学、中科院合肥物质科学院吴正岩课题组进行直博学习和研究，此后赴新加坡国立大学David Tai Leong课题组开展博士后研究。2020年起在山东省肿瘤医院于金明院士放射免疫与分子影像平台学习。2021年加入山东第一医科大学，主要从事疾病纳米诊疗体系开发等方面研究，

二、研究方向

纳米药物、生物材料、分子影像

三、项目、获奖及荣誉情况概述

以第一或通讯作者发表SCI论文33篇，其中IF>20有2篇，IF>10有16篇（近2年12篇），近2年申请发明专利近20项；主持国家级课题2项（国自然面上项目2023+青年项目2021）、省级课题4项；2023年获山东省医学会科技奖、山东省医学会青年科技奖、山东第一医科大学科学技术二等奖；2023年获校“优秀教师”、“校双带头人”等荣誉称号；现为Exploration、Interdisciplinary Medicine等杂志青年编委及AFM、Nano Letters等杂志审稿人。

四、研究成果

[1] G. Ma#, X. Zhang#, K. Zhao#, S. Zhang, K. Ren, M. Mu, C. Wang, X. Wang, H. Liu*, J. Dong*, X. Sun*. Polydopamine nanostructure-enhanced water interaction with pH-responsive manganese sulfide nanoclusters for tumor magnetic resonance contrast enhancement and synergistic ferroptosis-photothermal therapy. ACS Nano, 2024, 18, 4, 3369-3381. (IF=17.1)

[2] S. Liu#, L. Tian#, M. Mu, Z. Liu, M. Dong, Y. Gong, X. Wang, H. Zhang*, Q. Meng*, X. Sun*. Advanced Healthcare Materials, 2024, Major Revision. (IF=10)

[3] H. Liu, M. Mu, Y. Hou, Y. Gong, C. Wang, G. Ma, K. Guo, L. Ma*, X. Sun*. Advanced Functional Materials, 2024, Major Revision. (IF=19)

[4] X. Xu#, S. Xu#, J. Wan#, D. Wang, X. Pang, Y. Gao, N. Ni, D. Chen*, X. Sun*. Disturbing Cytoskeleton by Engineered Nanomaterials for Enhanced Cancer Therapeutics. Bioactive Materials, 2023, 29, 50–71. (IF=18.9)

[5] X. Zhang, H. Ge, Y. Ma, L. Song, Y. Ma, G. Tian, L. Wang, Q. Meng*, X. Sun*. Engineered Anti-cancer Nanomedicine for Synergistic Ferroptosis-Immunotherapy. Chemical Engineering Journal, 2023, 455, 140688. (IF=16.744)

[6] X. Zhang, X. Xu, H. Liu, N. Ni, S. Liu, Y. Gong, G. Ma, L. Song, Q. Fan*, Q. Meng*, X. Sun*. CCR2-overexpressing Biomimetic Carrier-free Nanoplatform for Enhanced Cascade Ferroptosis Tumor Therapy. Acta Biomaterialia, 2023, 166, 604-614. (IF=10.633)

[7] X. Xu, A. Liu, S. Liu, Y. Ma, X. Zhang, M. Zhang, J. Zhao, S. Sun, X. Sun*. Application of Molecular Dynamics Simulation in Self-assembled Cancer Nanomedicine. Biomaterials Research, 2023, 27, 39. (IF=15.863)

[8] S. Xu, X. Pang, X. Zhang, Q. Lv, M. Zhang, J. Wang, N. Ni, X. Sun*. Nanomaterials disrupting cell-cell junctions towards various diseases. Nano Research, 2023, 16, 7053–7074. (IF=10.263)

[9] W. Tian, C. Wang, R. Chu, H. Ge, X. Sun*, M. Li*. Injectable hydrogel nanoarchitectonics with near-infrared controlled drug delivery for in situ photothermal/endocrine synergistic therapy. Biomaterials Research, 2023, 27, 100. (IF=15.863)

[10] Y. Gao, S. Liu, H. Liu, H. Ge, M. Zhang, C. Zhao, Y. Gong, X. Zhang, C. Wang*, X. Sun*, Z. Wu*. Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine. Science China Chemistry, 2023, 66, 2492-2512. (IF=10.138)

[11] M. Liu, J. Yuan, G. Wang, N. Ni, Q. Lv, S. Liu, Y. Gong, X. Zhao, X. Wang*, X. Sun*. Shape Programmable T1-T2 Dual-Mode MRI Nanoprobes for Cancer Theranostics. Nanoscale, 2023, 15, 4694-4724. (IF=8.31)

[12] G. Ma, K. Wang, X. Pang, S. Xu, Y. Liang, J. Yang, X. Zhang, X. Sun*, J. Dong*. Self-assembled nanomaterials for ferroptosis-based cancer theranostics. Biomaterials Science, 2023, 11, 1962-1980. (IF=7.59)

[13] C. Wang, Y. Wang, W. Tian, S. Li, J. Wan, Y. Wang, L. Tian, X. Wang, C. Li, J. Wan*, X. Sun*. Application of nanomaterials with sulfur vacancy for enhanced cancer theranostics. Nano TransMed. 2023, 2, 100007.

[14] W. Wang, X. Pang, M. Dong, R. Li, Z. Liu, Y. Liang, H. Liu, N. Ni, D. Chen*. X. Sun*. Recent advances of nanomaterials promoting tumor metastasis. Environment & Health, 2023, 1, 367-382. (Supplementary Cover)

[15] N. Ni, X. Zhang, Y. Ma, J. Yuan, D. Wang, G. Ma, J. Dong*, X. Sun*. Biodegradable Two-Dimensional Nanomaterials for Cancer Theranostics. Coordination Chemistry Reviews, 2022, 458, 214415. (IF=24.833）

[16] J. Liu, M. Huang, X. Zhang, Z. Hua, Z. Feng, Y. Dong, T. Sun*, X. Sun*, C. Chen*. Polyoxometalate Nanomaterials for Enhanced Reactive Oxygen Species Theranostics. Coordination Chemistry Reviews, 2022, 472，214785. (IF=24.833）

[17] N. Ni, W. Wang, Y. Sun, X. Sun*, D. T. Leong*. Inducible endothelial leakiness in nanotherapeutic applications. Biomaterials, 2022, 287, 121640. (IF=15.304）

[18] H. Zhang, M. Zhang, X. Zhang, Y. Gao, Y. Ma, H. Chen, J. Wan, C. Li, F. Wang*, X. Sun*. Enhanced postoperative cancer therapy by iron-based hydrogels. Biomaterials Research, 2022, 26, 19. (IF=15.863）

[19] Y. Xu, Z. Nie, N. Ni, X. Zhang, J. Yuan, Y. Gao, Y. Gong, S. Liu, M. Wu*, X. Sun*. Shield-Activated Two-Way Imaging Nanomaterials for Enhanced Cancer Theranostics. Biomaterials Science, 2022, 10, 6893-6910. (IF=7.590)

[20] X. Sun#, R. Du#, L. Zhang#, G. Zhang, X. Zheng, J. Qian, X. Tian, J. Zhou, J. He, Y. Wang, Y. Wu, K. Zhong, D. Cai*, D. Zou*, Z. Wu*. A pH-responsive yolk-like nanoplatform for tumor targeted dual-mode magnetic resonance imaging and chemotherapy. ACS Nano, 2017, 11, 7049-7059.（IF=18.027）

[21] X. Sun#, G. Zhang#, R. Du#, R. Xu, D. Zhu, J. Qian, G. Bai, C. Yang, Z. Zhang, X. Zhang, D. Zou*, Z. Wu*. A Biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode MR imaging guided combinatorial cancer therapy. Biomaterials, 2019, 194, 151-160.（IF=15.304）

[22] X. Sun#, M. Zhang#, R. Du#, X. Zheng, C. Tang, Y. Wu, J. He, W. Huang, Y. Wang, Z. Zhang, X. Han, J. Qian, K. Zhong, X. Tian, L. Wu, G. Zhang, Z. Wu*, D. Zou*. A polyethyleneimine-driven self-assembled nanoplatform for fluorescence and MR dual-mode imaging guided cancer chemotherapy. Chemical Engineering Journal, 2018, 350, 69-78.（IF=16.744）

[23] X. Sun*, N. Ni, Y. Ma, Y. Wang, D. T. Leong*. Retooling Cancer Nanotherapeutics' Entry into Tumors to Alleviate Tumoral Hypoxia. Small, 2020, 16, 2003000.（IF=15.153）

[24] Y. Cao, K. Wang, P. Zhu, X. Zou, G. Ma, W. Zhang, D. Wang, J. Wan, Y. Ma, X. Sun*, J. Dong*. A near-infrared triggered upconversion/MoS2 nanoplatform for tumour-targeted chemo-photodynamic combination therapy. Colloids and Surfaces B: Biointerfaces, 2022, 213, 112393. (IF=5.999）

[25] H. Wang, X. Zhao, H. Zhang, X. Zou, D. Jia, W. Liu, B. Tian, D. Yuan, Y. Li, Y. Zhu, F. Zhang, Y. Dai, Y. Fan, Y. Wei, X. Sun, Q. Fan, J. Dong. EGFR-antagonistic affibody-functionalized Pt-based nanozyme for enhanced tumor radiotherapy. Materials Today Advances, 2023, 18, 100375. (IF=9.918)

[26] T. Tang, Y. Gong*, Y. Gao, X. Pang, S. Liu, Y. Xia, D. Liu, L. Zhu, Q. Fan*, X. Sun*. A pH-Responsive Liposomal Nanoplatform for Co-delivery of a Pt(IV) Prodrug and Cinnamaldehyde for Effective Tumor Therapy. Frontiers in Bioengineering and Biotechnology, 2023, 1191534. (IF=6.064)

[27] X. Zou, G. Ma, P. Zhu, Y. Cao, X. Sun*, H. Wang*, J. Dong*. A Polydopamine-Coated Platinum Nanoplatform for Tumor Targeted Photothermal Ablation and Migration Inhibition. Frontiers in Oncology. 2022, 12, 860718. (IF=5.738）

[28] X. Zhang, Y. Ma, J. Wan, J. Yuan, D. Wang, W. Wang, X. Sun*, Q. Meng*. Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics. Frontiers in Chemistry, 2021, 9, 768248. (IF=5.545）

[29] N. Ni, Y. Su, Y. Wei, Y. Ma, L. Zhao*, X. Sun*. Tuning nanosiliceous framework for enhanced cancer theranostic applications. Advanced Therapeutics, 2021, 16, 2000218. (IF=5.003）

[30] D. Wang, Y. Wang, Q. Lv, X. Zhang, G. Ma, Y. Gao, C. Wang, S. Liu, C. Li*, X. Sun*, J. Wan*. A polyoxometalate encapsulated metal-organic framework nanoplatform for synergistic photothermal-chemotherapy and anti-inflammatory of ovarian cancer. Molecules, 2022, 27(23), 8350. (IF=4.927）

[31] X. Sun#, G. Zhang#, Z. Wu*. Nanostructures for pH-sensitive drug delivery and magnetic resonance contrast enhancement systems. Current Medicinal Chemistry, 2018, 25, 3036-3057.（IF=4.74）

[32] X. Sun#, C. Cai#, Q. Wang, D. Cai, J. Qian, Y. Chi, K. Zheng, X. Zhang, G. Zhang*, K. Zhong*, Z. Wu*. A polyethylenimine functionalized porous/hollow nanoworm as a drug delivery system and a bioimaging agent. Physical Chemistry Chemical Physics, 2016, 18, 7820-7828.（IF=3.945）

[33] M. Wang#, X. Sun#, N. Zhong, D. Cai*, Z. Wu*. Promising Approach for Improving Adhesion Capacity of Foliar Nitrogen Fertilizer. ACS Sustainable Chemistry & Engineering, 2015, 3, 499-506.（IF=9.224）

五、联系方式

办公电话：15064071363

电子邮箱：sunxiao@sdfmu.edu.cn; chebiosx@126.com

实验室网址：https://www.x-mol.com/groups/sun_xiao

主要办公地址：山东省济南市槐荫区青岛路山东第一医科大学科创中心，邮编：250000