一、个人简介

张磊亮，研究员，博士生导师，泰山学者特聘专家。本科和博士毕业于北京大学生命科学学院，哈佛大学医学院和佛罗里达大学博士后，曾任中国医学科学院/北京协和医学院病原生物学研究所课题组长（PI）。在PNAS、J Hepatol、J Virol、J Infect等SCI杂志上发表论文90余篇。任山东省医学会微生物与免疫学分会副主任委员，Microbiology Spectrum杂志编委。指导本科生获得挑战杯（大挑）国赛二等奖，挑战杯（小挑）省赛金奖和银奖，基础医学创新研究暨实验设计论坛国赛3项金奖和2项银奖。

二、研究方向

以正痘病毒、基孔肯雅病毒、新冠病毒等医学病毒为研究对象，围绕宿主膜运输与病毒相互作用进行深入探索，开展病毒传染和致病性机制相关研究。

三、项目、获奖及荣誉情况概述

主持6项国家自然科学基金面上项目和5项省部级基金。获山东省优秀研究生指导教师，山东省留学人员回国创业奖，山东省医学会医学科技进步奖三等奖，中国医学科学院“协和新星”，山东第一医科大学优秀教师，全国大学生基础医学创新研究暨实验设计论坛总决赛优秀指导教师。

四、研究成果

[1] Xu T, Li D, Luan J, Zhang L*. Dasabuvir: An FDA-approved drug inhibiting poxvirus transmission by targeting both migrasome formation and extracellular enveloped virus production. Journal of Infection 2025, 90(2):106403

[2] Zhao W, Tang X, Zhang L*. Virus-containing migrasomes enable poxviruses to evade tecovirimat/ST-246 treatment. Journal of Infection. 2024, 88(2):203-205

[3] Lv L, Zhang L*.  Identification of poxvirus inside migrasomes suggests a novel mode of mpox virus spread. Journal of Infection. 2023, 87(2):160-162

[4] Zhang N#, Gao S#, Zhang L*. Chikungunya virus nsP1 induces migrasome formation. Journal of Infection. 2022, 85(5):e158-e161

[5] Lv L, Li A, Jiang L, Zhang L*. Deficiency of HTR4 and ADRB1 caused by SARS-CoV-2 spike may partially explain multiple COVID-19 related syndromes including depression, cognitive impairment, loss of appetite, heart failure, and hypertension. Journal of Infection. 2023; 86(2):191-194

[6] Ren Y#, Liu Y#, Zhang Z, Liu Y, Li K, Zhang L*. SNX27-mediated endocytic recycling of GLUT1 is suppressed by SARS-CoV-2 spike, possibly explaining neuromuscular disorders in patients with COVID-19. Journal of Infection. 2022, 85(4):e116-e118

[7] Ren Y, Lv L, Li P, Zhang L*. Inhibition of endocytic recycling of ACE2 by SARS-CoV-2 S protein partially explains multiple COVID-19 related diseases caused by ACE2 reduction. Journal of Infection. 2022, 85(1):e21-e23

[8] Gao S#, Lu Y#, Luan J, Zhang L*. Low incidence rate of diarrhoea in COVID-19 patients is due to integrin. Journal of Infection. 2021, 83(4):511-513

[9] Li D#, Liu Y#, Li K, Zhang L*. Targeting F13 from monkeypox virus and variola virus by tecovirimat: molecular simulation analysis. Journal of Infection. 2022, 85(4):e99-e101

[10] Zhang N, Zhao H, Zhang L*. Fatty acid synthase promotes the palmitoylation of Chikungunya virus nsP1. Journal of Virology. 2019;93(3):e01747-18