一、个人简介

副教授，硕、博毕业于中国农业大学化学专业。本课题组研究聚焦“功能杂环合成”这一目标，利用光催化、电诱导、过渡金属以及有机小分子催化等手段，发展绿色、高效、化学经济性高的杂环构建方法。近年来已经成功构建了约400余种新颖杂环构架分子。先后承担省级以上科研及人才项目3项，相关研究发表在Chem.Sci., Org.Lett., Chmm. Commun., J. Org. Chem., Org. Biomol.Chem.等期刊，发表SCI论文20余篇。

二、研究方向

1、光、过渡金属协同催化不对称环化反应；

2、金属稳定π-烯丙基两性离子参与杂环构建；

3、有机小分子催化活性中间体构建杂环化合物；

4、杂环化合物库构建及农药、医药活性筛选。

三、项目、获奖及荣誉情况概述

1、山东省自然科学基金青年项目立项（ZR202110110024）

2、苏州市高新区创新创业人才（孵化）

3、江苏省高校面上基金（21KJB150011）

4、山东第一医科大学 科教融合-人才队伍建设（YS22-0002019）

四、代表性研究成果

1、Huawei Lin,‡ Biming Mao,‡ Bing Han, Jiayi Luo, Yanqing Ge, Xuerui Zhang, Chang Wang,* Hongchao Guo,* Chunhao Yuan*, Palladium-catalyzed ^[4+4] cycloaddition of 2-pyrones with 2-alkylidenetrimethylene carbonates: access to bridged eightmembered oxygen heterocycles. Org. Chem. Front., 2024, Accepted Manuscript. doi.org/10.1039/D4QO00329B

2、Huawei Lin, Xinyan Hu, Bing Han, Xianru Yang, Yiwei Deng, Jiayi Luo, Yanqing Ge, Biming Mao*, Chang Wang*, and Chunhao Yuan*, Facile Synthesis of Quinoline-Substituted 3-Hydroxy-2-oxindoles and 3-Amino-2-oxindoles via a Palladium-Catalyzed Cascade Intramolecular Cyclization/Intermolecular Nucleophilic Addition Reaction. J. Org. Chem. 2024, 89, 5, 3413–3418.

3、Fan Wu, Yu Guo, Zihao Ren, Zixuan Chen, Xiaoqin Liu,* Chang Wang,* and Liangce Rong*, Electrochemical Radical Reactions of Enol Acetates and Free Alcohols Directly Access to α‑Alkoxylated Carbonyl Compounds. J. Org. Chem. 2023, 88, 8825−8834.

4、Huawei Lin, Xianru Yang, Wenyue Ning, Xiaofang Huang, Xiaoqun Cao, Yanqing Ge, Biming Mao, Chang Wang,* Hongchao Guo, and Chunhao Yuan*, Palladium-Catalyzed Asymmetric Cascade Intramolecular Cyclization/Intermolecular Michael Addition Reaction of Allenyl Benzoxazinones with 1‑Azadienes. Org. Lett. 2022, 24, 9442−9446.

5、Qiuyu Yu, Jinghang Zhang, Fan Wu, Xiaoqin Liu, Chang Wang,* Jinpeng Zhang,* and Liangce Rong*. Propargyl Chalcones’ Radical Annulation/Sulfonation Reaction: Efficient Synthesis of Benzo[b]oxepin-5(2H)‑one and Chromane Derivatives. J. Org. Chem. 2022, 87, 7136−7149.

6、Huawei Lin, Jing Gu, Shan Luo, Qilong Gu, Xiaoqun Cao, Yanqing Ge, Chang Wang,* Chunhao Yuan,* Hai Wang.* DBU-Catalyzed [3+2] Cycloaddition of Benzoaurones with 3-Homoacyl Coumarins: Synthesis of Spiro[Benzofuranone-Cyclopentane] Compounds. ChemistrySelect 2022, 7, e202201599. Doi.org/10.1002/slct.202201599.

7、Lei Dai, Qiuyu Yu, Jinghang Zhang, Fan Wu, Chang Wang*, Jinpeng Zhang*, and Liangce Rong*. Electrochemical Radical δ-H Sulfonylation Reaction for the Synthesis of 4-((Aryl,Arylsul fonyl)methylene)-2,5-Cyclohexadiene Derivatives. J. Org. Chem. 2021, 86, 15, 10568–10579.

8、Kaimin Mao, Mouwang Bian, Lei Dai, Jinghang Zhang, Qiuyu Yu, Chang Wang*, and Liangce Rong*, Metal-Free Radical Annulation of Oxygen-Containing 1,7-Enynes: Configuration-Selective Synthesis of (E)-3-((Arylsulfonyl)methyl)-4-Substituted Arylidene-chromene Derivatives.Org. Lett., 2021, 23, 1, 218–224.

9、Yan Gu,# Lei Dai,# Jinghang Zhang, Xinchi Lu, Xiaoqin Liu, Chang Wang,* Jinpeng Zhang,*and Liangce Rong*. Silver-Catalyzed Radical Cascade Sulfonation/Cycloaddition for the Construction of Multifunctional Succimides Containing Separable Z/E‑Isomers. J. Org. Chem. 2021, 86, 2173−2183.

10. Chang Wang, Yuehua Chen, Jingyu Li, Leijie Zhou, Bo Wang, Yumei Xiao, and Hongchao Guo. Phosphine-Catalyzed Asymmetric Cycloaddition Reaction of Diazenes: Enantioselective Synthesis of Chiral Dihydropyrazoles. Org. Lett. 2019, 21, 7519−7523.