一、研究所介绍
山东第一医科大学科创中心环境与健康研究所聚焦物理、化学、生物等环境因素对人体健康、疾病发生、衰老的影响，重点围绕气候变化、高风险环境因素、新污染物引发/促进造血障碍、免疫缺陷、代谢紊乱、癌症、病原微生物感染、神经/骨退行性疾病等重大疾病开展相关研究，并探究如何利用纳米诊疗体系实现疾病的精准诊断和有效干预，实现从环境分析、诊疗研发和效应机制研究的有机结合。研究所现有教授/研究员10余人，其中，国家杰青1人、山东省泰山学者7人、山东省优青1人、山东省海外优青1人。
二、课题组
三、研究成果
（一）项目、论文、获奖等情况概述
自成立以来，研究所获得包括国家重点研发计划等国家级项目30余项，在Cell、Cell Metabolism、Blood、Advanced Materials等期刊发表多篇高水平研究论文。
（二）代表性成果
1. Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schöneberg T, Liebscher I, Xu HE, Sun JP. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. 2022 Apr;604(7907):763-770.
2. Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex. Nature. 2021 Jan;589(7843):620-626.
3. Liu W, Wu Y, Wei H, Ma J, Feng W, Yang Q, Zhang S, Ganz T, Liu S. Lactate administration improves laboratory parameters in murine models of iron overload. Blood. 2024 Mar 14;143(11):1045-1049.
4. Liu W, Zhang S, Li Q, Wu Y, Jia X, Feng W, Li Z, Shi Y, Hou Q, Ma J, Liu Y, Gao P, Ganz T, Liu S. Lactate modulates iron metabolism by binding soluble adenylyl cyclase. Cell Metab. 2023 Sep 5;35(9):1597-1612.
5. Dong Z, Ma J, Qiu J, Ren Q, Shan Q, Duan X, Li G, Zuo YY, Qi Y, Liu Y, Liu G, Lynch I, Fang M, Liu S. Airborne fine particles drive H1N1 viruses deep into the lower respiratory tract and distant organs. Sci Adv. 2023 Jun 9;9(23):eadf2165.
6. Wang C, Zhang W, He Y, Gao Z, Liu L, Yu S, Hu Y, Wang S, Zhao C, Li H, Shi J, Zhou W, Li F, Yue H, Li Y, Wei W, Ma G, Ma D. Ferritin-based targeted delivery of arsenic to diverse leukaemia types confers strong anti-leukaemia therapeutic effects. Nat Nanotechnol. 2021 Dec;16(12):1413-1423.
7. Wang C, Wang X, Zhang W, Ma D, Li F, Jia R, Shi M, Wang Y, Ma G, Wei W. Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents. Adv Mater. 2022 Feb;34(5):e2107150.
8. Pajtler KW, Wei Y, Okonechnikov K, Silva PBG, Vouri M, Zhang L, Brabetz S, Sieber L, Gulley M, Mauermann M, Wedig T, Mack N, Imamura Kawasawa Y, Sharma T, Zuckermann M, Andreiuolo F, Holland E, Maass K, Körkel-Qu H, Liu HK, Sahm F, Capper D, Bunt J, Richards LJ, Jones DTW, Korshunov A, Chavez L, Lichter P, Hoshino M, Pfister SM, Kool M, Li W, Kawauchi D. YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis. Nat Commun. 2019 Sep 2;10(1):3914.
9. Dong Z, Liu Y, Wang C, Hao Y, Fan Q, Yang Z, Li Q, Feng L, Liu Z. Tumor Microenvironment Modulating CaCO3 -Based Colloidosomal Microreactors Can Generally Reinforce Cancer Immunotherapy. Adv Mater. 2024 Mar;36(9):e2308254.
10. Dou S, Wang Q, Zhang B, Wei C, Wang H, Liu T, Duan H, Jiang H, Liu M, Qi X, Zhou Q, Xie L, Shi W, Gao H. Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis. Cell Discov. 2022 Jul 12;8(1):66.
四、联系方式
联系人：张书平(spzhang@sdfmu.edu.cn)
办公地点：科创大楼C301
