一、个人简介

吕翠，博士，副教授，硕士生导师，省高校青创团队带头人。团队主要聚焦国家重大疾病防治战略，以阿尔茨海默病等疾病的中西医防治和生物标志物的转化医学研究为主要研究方向，主持和参与国家自然科学基金面上项目和山东省自然科学基金面上项目等省部级及以上项目 10 余项。近年来以临床问题为导向开展基础医学研究，在国际一流期刊《Cellular & Molecular Immunology》（IF=22.1）等免疫学和神经病学领域期刊发表论文 20 余篇。通过与临床医生合作，对中国传统“象思维”、中医髓认知与现代神经免疫学研究等中西医研究成果融合创新，系统地提出诸髓一体、同源、同属的“泛髓学说”，创建中医脑病防治的泛髓靶向研究体系，该成果突破了西医对人体系统分类的认识，为中医脑病泛髓一体化防治提供理论指导，为中、西医学融合创新提供新思路新应用，该成果也获得“山东省科技进步奖二等奖”。同时基于神经免疫轴对多种神经系统疾病的发病机制和治疗策略开展研究，第一完成人获济南市优秀自然科学学术成果奖一等奖和山东省分析测试协会科学技术奖一等奖等多项科研奖励，第一完成人授权国家发明专利2项，担任山东免疫学会青年工作委员会常务委员和山东中医药学会中医基础理论专业委员会委员等。

二、代表论著

1. Cui Lv*; Hao Zhang*; Zifa Li; Hao Zhang; Yu Zhang; Ronghui Li; Sheng Wei#; Di Yu#; Low-dose IL-2 therapy compensates for metabolic shifts and reverses anxiety-like behavior in PD-1 defificiency-induced autoimmunity, Celluar&Molecular Immunology, 2021, 18(5): 1336-1338.（IF=22.1，TOP期刊）

2. Lin Yuan; Lei Xie; Hao Zhang; Yu Zhang; Yunbo Wei; Jinhong Feng; Li Cui; Rui Tian; Jia Feng; Di Yu#; Cui Lv#; Low‑dose IL‑2 Treatment Rescues Cognitive Deficits by Repairing the Imbalance Between Treg and Th17 Cells at the Middle Alzheimer’s Disease Stage. Journal of Neuroimmune Pharmacology, 2023,18:674-689.

3. Cui Lv*; Lei Wang*; Xiaoli Liu; Shijun Yan; Shirley ShiDu Yan; Yongyan Wang; Wensheng Zhang#; Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model, Neuropharmacology, 2015, 89: 175-184.

4. Cui Lv, Xiaoli Liu, Zhi Li, Hongjuan Liu, Tong Chen, Wensheng Zhang#, Geniposide attenuates memory deficits by targeting mitochondria in APP/PS1 transgenic mice, Current Alzheimer Research, 2014, 11(6): 576-584.

5. Cui Lv, Lei Wang, Xiaoli Liu, Xiao Cong, Shirley ShiDu Yan, Yongyan Wang, Wensheng Zhang#, Geniposide attenuates oligomeric Aβ1-42-induced inflammatory response by targeting RAGE-dependent signaling in BV2 cells, Current Alzheimer Research, 2014, 11(5): 430-440.

6. Chunhui Zhao*, Cui Lv*, Hang Li , Shijing Du, Xiaoli Liu, Zhi Li ,Wenfeng Xin, Wensheng Zhang#, Geniposide Protects Primary Cortical Neurons against oligomeric Aβ1-42-induced neurotoxicity through a mitochondrial pathway, Plos One. 2016, 11(4):e0152551.

7. Chong Liu*; Dongxiao Li*; Cui Lv; Zhisong Gao; Yinkuang Qi; Hongran Wu; Yunyun Tian; Yansu Gu#; Activation of the Notch Signaling Pathway and Cellular Localization of Notch Signaling Molecules in the Spinal Cord of SOD1-G93A ALS Model Mice, Neuroscience, 2020, 432: 84-96.

8. Chunhui Zhao; Ping Su; Cui Lv; Limin Guo; Guoqiong Cao; Chunxia Qin; Wensheng Zhang#; Berberine Alleviates Amyloid β-Induced Mitochondrial Dysfunction and Synaptic Loss, Oxidative Medicine and Cellular Longevity, 2019, 8: 1-11.

9. Haijing Zhang; Chunhui Zhao; Cui Lv; Xiaoli Liu; Shijing Du; Zhi Li; Yongyan Wang; Wensheng Zhang#; Geniposide alleviates Amyloid-inducedsynaptic injury by protecting axonal mitochondrial trafficking, Frontiers in Celluar Neuroscience, 2017, 10(309).

10. Jinhong Feng; Ting Zheng; Zhaohua Hou; Cui Lv; Anqi Xue; Tingting Han; Beibei Han; Xin Sun; Yunbo Wei# ; Luteolin, an aryl hydrocarbon receptor ligand, suppresses tumor metastasis in vitro and in vivo, Oncology Reports, 2020, 44(5): 2231-2240

三、招生要求

学术型，偏向生物、基础医学方向

专业型：偏向中医药方向