一 、个人简介

王双连，烟台莱州人，1979年生人。2003年在安徽理工大学医学院获得临床医学学士学位，同年考入山东大学医学院，2006和2011年先后获得医学生理学硕士和博士学位。攻读博士学位期间，在国家留学基金委建设高水平大学研究生项目支持下，以山东大学-多伦多大学联合培养博士生的身份在加拿大多伦多大学和西安大略大学完成博士和博士后训练（2007-2011年）。

2011年9月留校任教，在山东大学基础医学院生理学与病理学系先后担任讲师，副教授，硕士生导师。2022年1月入职我校科创中心，被聘为教授，硕士生导师，并担任消化系统稳态与疾病实验室PI，研究方向为肝脏稳态与疾病。主持完成国家自然科学基金两项，山东省自然科学基金一项，以第一或通讯作者发表多篇SCI论文。教学方面，主编教材一部：《消化系统》（以器官和系统为核心的混合式教学系列教材，清华大学出版社），参编教材人民卫生出版社教材一部：《生理学》（临床医学专业本科生全国统编教材），主持山东省一流课程一项。

二 、代表论著

（1）Ziyou Bao, Xiaotong Chen, Yan Li, Wenshan Jiang, Di Pan, Lushun Ma, Yunxiao Wu, Yunling Chen, Chaojia Chen, Liyuan Wang, Songbo Zhao, Tixiao Wang, Wei-Yang Lu*, Chunhong Ma*, Shuanglian Wang*. The hepatic GABAergic system promotes liver macrophage M2 polarization and mediates HBV replication in mice. Antiviral Research. 217 (2023) 105680

（2） Qiao He, Zhaoqing Yin, Yunling Chen, Yunxiao Wu, Di Pan, Yuanhao Cui, Zinuo Zhang, Hanyu Ma, Xuanji Li, Chang Shen, Junfang Qin*, Shuanglian Wang*. Cyanidin-3-O-glucoside alleviates ethanol-induced liver injury by promoting mitophagy in a Gao-binge mouse model of alcohol-associated liver disease. BBA - Molecular Basis of Disease 1870 (2024) 167259.

(3) Cong Song, Zhijun Ouyang, Junjie Liu, Mengsi Zhan, Zinuo Zhang, Mingwu Shen, Shuanglian Wang*, Xiangyang Shi*, Shaojun Peng*. Core-shell tecto dendrimers co-deliver drug/gene for immunomodulation of macrophages and dendritic cells and checkpoint blockade-promoted breast cancer chemoimmunotherapy. Nano Today 58 (2024) 102437.

(4) Yao Shi, Haojie Zhang, Shuang Li, Danqing Xin, Shiyang Li, Bing Yan, Shuanglian Wang*, Chuanyong Liu*. Procyanidin improves experimental colitis by regulating macrophage polarization. Biomedicine & Pharmacotherapy 165 (2023) 115076.

(5) Hao Feng, Zongxin Sun, Baoshi Han, Huitang Xia, Lumei Chen, Chunlei Tian, Suhua Yan, Yugen Shi, Jie Yin, Wengang Song, Peipei Gong, Shuanglian Wang*, Yan Li*. Miro2 sulfhydration by CBS/H2S promotes human trophoblast invasion and migration via regulating mitochondria dynamics. Cell Death & Disease (2024) 15:776.

(6) Shuang Li, Yao Shi, Jianchun Zhu, Jingxin Li, Shuanglian Wang*, Chuanyong Liu. Protective effect of oxytocin on vincristine-induced gastrointestinal dysmotility in mice. Frontiers in Pharmacology (2024) Apr 9:15:1270612.

(7) Yunling Chen, Zhaoqing Yin, Xiaonan Zhang, Yiwei Zhao, Tinghao Liu, Wei-Yang Lu*, Shuanglian Wang* Increased GABA signaling in liver macrophage promotes HBV replication in HBV-carrier mice. Virus Research 344 (2024) 199366. 

(8) ZhuoWang#, Shuanglian Wang#, Chen Gao, Xuantao Su. Deep learning based label-free small extracellular vesicles analyzer with light-sheet illumination differentiates normal and cancer liver cells. Sensors and Actuators B: Chemical Volume 347, 15 November 2021.

(9) Shuanglian Wang, Xie DP, Liu KJ, Qin JF, Feng M, Kunze W and Liu CY. Nitric oxide mediates the inhibitory effect of ethanol on the motility of isolated longitudinal muscle of proximal colon in rats. Neurogastroenterology and Motility 2007 Jun; 19 (6): 515-21.

(10) Shuanglian Wang#, Yun-Yan Xiang#, Russ Ellis, Jennifer Wattie, Mark D. Inman and Wei-Yang Lu. Effects of furosemide on allergic asthmatic responses in mice. Clinical & Experimental Allergy 2011 (41) 1456–1467.

三、招生要求

学术型：偏向基础医学或生物学方向

专业型：偏向医学技术方向