一、个人简介
郭玉娜，博士，山东第一医科大学副研究员，硕士生导师，泰山学者青年专家。2021年毕业于南京大学生命分析化学国家重点实验室，获博士学位，并于同年加入山东第一医科大学，国家杰青课题组工作。长期致力于分析化学与疾病诊断、调控领域的交叉研究，聚焦糖生物学与化学生物学，推动癌症早期诊断、细胞工程及再生医学等前沿领域的突破性进展。
近年来主持了国家自然科学基金青年项目、山东省自然科学基金青年项目等重要科研课题，并以第一作者或通讯作者身份在国际顶级学术期刊上发表SCI论文十余篇，其中包括两篇发表于化学类顶刊Journal of the American Chemical Society，此外，还在JACS Au、Trends in Analytical Chemistry、Biosensors and Bioelectronics等国际知名期刊上，以通讯作者身份发表了多篇研究成果，获得了国内外同行的高度评价与广泛引用。
研究工作涵盖了细胞特异性标记、外泌体糖基化分析、糖基修饰调控等领域，尤其是在基于适体-酶偶联的邻近催化标记技术方面，提出了一种全新的思路，实现了细胞表面糖基的精确修饰和细胞-细胞相互作用的调控，为肿瘤干预研究提供了具有前瞻性的技术平台。围绕癌症标志物的高灵敏检测方法，研究成果为精准医学的发展和早期诊断提供了重要支持。
二、代表论著
1. Guo, Yuna#; Wang, Nan#; Zhong, Yihong#; Li, Wei; Li, Yiran; Wang, Guyu; Yao, Yuyan; Shi, Yue; Chen, Liusheng; Wang, Xiaojian; Ding, Lin*; Ju, Huangxian. Cell-selective multifunctional surface covalent reconfiguration using aptamer-enabled proximity catalytic labeling. Journal of the American Chemical Society, 2023, 145(9): 5092-5104.
2. Guo, Yuna; Tao, Jing; Li, Yiran; Feng, Yimei; Ju, Huangxian; Wang, Zhongfu; Ding, Lin*. Quantitative localized analysis reveals distinct exosomal protein-specific glycosignatures implications in cancer cell subtyping, exosome biogenesis, and function. Journal of the American Chemical Society, 2020, 142(16): 7404-7412.
3. Wei, Yuan; Zheng, Lei; Chen, Ying; Jiao, Jianwei*; Jiao, Jin*; Guo, Yuna*. Analyzing and modifying sialic acid at the glycan end: Systematic review of methods and functional outcomes. Trends in Analytical Chemistry, 2024, 183: 118083.
4. Wang, Gang#; Chen, Ying#; Wei, Yuan; Zheng, Lei; Jiao, Jianwei*; Guo, Yuna*. Highly Sensitive Labeling, Clickable Functionalization, and Glycoengineering of the MUC1 Neighboring System. JACS Au, 2024, 4: 828-836.
5. Guo, Yuna*; Wang, Pingping; Jiang, Liangyu; Deng, Chaowen; Zheng, Lei; Song, Cong*; Jiao, Jianwei*. Multifunctional Proximity Labeling Strategy for Lipid Raft-Specific Sialic Acid Tracking and Engineering. Bioconjugate Chemistry, 2023, 34: 1719-1726.
6. Niu, Xiankai#; Guo, Yiqun#; Li, Na; Li, Siyu; Yu, Yilei; Jiao, Jianwei*; Guo, Yuna*. Intelligent molecular cleavage and dual-signal relay amplification ratiometric strategy for high-sensitivity analysis and dynamic monitoring of exosomal RNA in glioma. Biosensors and Bioelectronics, 2025, 274: 117205.
7. Guo, Yuna; Jia, Wenshuang; Yang, Jingru; Zhan, Xianquan*. Cancer glycomics offers potential biomarkers and therapeutic targets in the framework of 3P medicin. Frontiers in Endocrinology, 2022, 13: 970489.
8. Guo, Yuna; Wang, Yu; Liu, Su; Yu, Jinghua; Wang, Hongzhi; Wang, Yalin; Huang, Jiadong*. Label-free and highly sensitive electrochemical detection of E. coli based on rolling circle amplifications coupled peroxidase-mimicking DNAzyme amplification. Biosensors and Bioelectronics, 2016, 75: 315-319.
9. Guo, Yuna; Wang, Yu*; Yu, Jinghua; Wang, Hongzhi; Liu, Xiaokun; Huang, Jiadong. Simultaneous voltammetric determination of E. coli and S. typhimurium based on target recycling amplification using self-assembled hairpin probes on a gold electrode. Microchimica Acta, 2017, 184(3): 745-752.
10. Guo, Yuna; Wang, Yu; Liu, Su; Yu, Jinghua; Wang, Hongzhi; Cui, Min; Huang, Jiadong*. Electrochemical immunosensor assay (EIA) for sensitive detection of E. coli O157:H7 with signal amplification on a SG-PEDOT-AuNPs electrode interface. Analyst, 2015, 140(2): 551-559.
三、招生要求
学术型：偏向化学生物学方向
专业型：偏向疾病诊断、公卫卫生方向
欢迎志同道合的朋友、同学联系，并肩作战，共同推动疾病诊断和细胞功能调控研究的创新与发展。
