一、个人简介

李文，2020年12月入职山东第一医科大学医学科技创新中心副研究员，硕士生导师。博士毕业于山东大学基础医学院免疫系，目前研究方向为感音神经性耳聋等疾病的发病机制及防治研究，主要聚焦于内耳毛细胞、听神经元等细胞类型与免疫细胞的交互作用研究。发表SCI论文数篇，近期在Autophagy、Molecular Therapy等权威期刊以第一作者发表论文。现任山东免疫学会青年工作委员会委员，山东省免疫学会微生态免疫专业委员会委员，山东省研究型医院协会杰出青年学者分会常务委员。校骨干人才引进项目一项（200万），目前承担国家自然基金一项（30万），山东省自然科学青年基金一项（15万）。

二、代表论著

1. Li W, Li Y, Guan Y, Du Y, Zhao M, Chen X, Zhu F, Guo C, Jia Y, Li Y, Wang X, Wang X, Shi Y, Wang Q, Li Y, Zhang L. TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis. Autophagy. 2021 Jun;17(6):1410-1425.

2. Wen Li, Yu Li, Min Wang, Hao Liu, Ziyi Liu,Xiuli Bi,Xiaoxu Zhao, Guodong Hong, Xiaolong Fu*. TNFAIP8L2 maintains Hair cell function and Regulates Age-related hearing loss via mTORC1 Signaling. Molecular Therapy. 2025 (Accepted).

3. Zhiwei Yao#, Yu Xiao#, Wen Li#, Shuhui Kong, Hailong Tu, Siwei Guo, Ziyi Liu, Lushun, Ruifeng Qiao, Song Wang, Miao Chang, Lei Xu*, Daqing Sun*, Xiaolong Fu*. FDA-approved Tedizolid Phosphate prevents cisplatin-induced hearing loss without decreasing its anti-tumor effect. Journal of the Association for Research in Otolaryngology: JARO, 2024 25(3), 259–275. 

4. Li W, Zhang L. Regulation of ATG and Autophagy Initiation. Adv Exp Med Biol. 2019;1206:41-65.

5. Liu Z, Zhang H, Hong G, Bi X, Hu J, Zhang T, An Y, Guo N, Dong F, Xiao Y, Li W, Zhao X, Chu B, Guo S, Zhang X, Chai R, Fu X. Inhibition of Gpx4-mediated ferroptosis alleviates cisplatin-induced hearing loss in C57BL/6 mice.Molecular Therapy. 2024 May 1;32(5):1387-1406.

6. Fu X, Wan P, Lu L, Wan Y, Liu Z, Hong G, Cao S, Bi X, Zhou J, Qiao R, Guo S, Xiao Y, Wang B, Chang M, Li W, Li P, Zhang A, Sun J, Chai R, Gao J. Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels. Advanced Science. 2023 Jul;10(20): e2300402.

7. Xiaotong Chen; Yetong Guan; Yi Zhang; Yufeng Jia; Wen Li; Chun Guo; Yuan Li; Xiaoyan Wang; Yongyu Shi; Qun Wang; Faliang Zhu; Yan Li; Lining Zhang; Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation., Cell Death & Differentiation. 2021, 28: 1237-1250

8. Yuan Zhang,Xiaolong Fu,Yiyuan, Li,Wen ,Guodong Hong,Siwei Guo,Yu Xiao,Ziyi Liu,Shuqin Ding,Xiuli Bi,Fanglei Ye,Jin Jin,Renjie Chai. Macrophage-mediated immune response aggravates hearing disfunction caused by the disorder of mitochondrial dynamics in cochlear hair cells. Hum Mol Genet. 2023 Mar 20;32(7):1137-1151

三、招生要求

学术型：偏向耳鼻喉科学、 基础医学、临床医学、医学生物化学与分子生物学、免疫学、神经病学

专业型：偏向耳鼻喉科学、 基础医学、临床医学、医学生物化学与分子生物学、免疫学、神经病学