一、个人简介

张贵强，博士，副教授，山东省青年创新团队带头人。博士毕业于中国科学院过程工程研究所，而后于山东大学化学与化工学院从事博士后研究。主要研究兴趣：（1）自组装纳米粒子在肿瘤免疫治疗和炎症相关疾病中的应用研究；（2）新型纳米疫苗设计及活性研究。以第一作者或通讯作者分别在Chemical Engineering Journal、Acta Biomaterialia、BMEMat、ACS Applied Materials & Interfaces、Chinese Chemical Letters等期刊上发表SCI期刊文章20余篇，授权专利5项。主持国家自然科学基金青年项目、中国博士后基金特别资助项目、山东省自然科学基金面上项目、山东省青年创新团队项目和山东中医药等项目，并参与了多项国家级和省部级课题研究。

二、代表论著

1. Jie Yan, Xuechun Wang, Yilei Zhao, Songyan Li, Zilin Ma, Yizheng Yang, Changping Gu*, Guiqiang Zhang*, Yuelan Wang*. Inflammation-Responsive Nanoparticles for Acute Lung Injury Treatment through Gas Therapy and Removal of Neutrophil Extracellular Traps. Chemical Engineering Journal 2025, accepted.

2. Xuechun Wang, Jie Yan, Yilei Zhao, Songyan Li, Zilin Ma, Xiuying Duan, Yuelan Wang, Jianwei Jiao*, Changping Gu*, Guiqiang Zhang*. Targeted degradation of EGFR mutations via self-delivery nano-PROTACs for boosting tumor synergistic immunotherapy. ACS Applied Materials & Interfaces 2025, accepted.

3. Houyang Hu, Jie Yan, Haijun Zhu, Xuechun Wang, Yilei Zhao, Songyan Li, Zilin Ma, Fenglei Xu, Ming Xia, Jianwei Jiao*, Miaoqing Zhao*, Guiqiang Zhang*. Self-delivered sonodynamic nanomedicine for enhanced tumor immunotherapy by simultaneously reversing the immunosuppression and immune resistance. Chemical Engineering Journal 2024, 501, 157580.

4. Yilei Zhao, Xiaonan Zhao, Xuechun Wang, Zilin Ma, Jie Yan, Songyan Li, Ning Wang, Jianwei Jiao*, Jiwei Cui*, Guiqiang Zhang*. Polyphenol-mediated assembly of Toll-like receptor 7/8 agonist nanoparticles for effective tumor immunotherapy. Acta Biomaterialia 2025, 193, 417-428.

5. Yilei Zhao, Guoxin Zhu, Xuechun Wang, Zilin Ma, Jie Yan, Songyan Li, Wen Zhao, Qingbin He*, Jianwei Jiao*, Guiqiang Zhang*. In situ carrier-free nanovaccines reversing the immunosuppressive microenvironment for boosting tumor immunotherapy. Chinese Chemical Letters 2025, 36, 111031.

6. Xiuying Duan, Yilei Zhao, Houyang Hu, Xuechun Wang, Houyang Hu, Xuechun Wang, Jie Yan, Songyan Li, Yueying Zhang*, Jianwei Jiao*, Guiqiang Zhang*. Amino acid metabolism-regulated nanomedicine for enhanced tumor immunotherapy through synergistic regulation of immune microenvironment. Biomaterials Research 2024, 28, 48.

7. Houyang Hu, Xuechun Wang, Yilei Zhao, Jie Yan, Songyan Li, Chengzhilin Li, Xiaonan Zhao, Kanaparedu Sekhar, Ming Xia, Jianwei Jiao*, Miaoqing Zhao*, Guiqiang Zhang*. Self-Assembled R848/Chlorin e6 Nanoparticles for Combinatorial Immunotherapy of Head and Neck Squamous Cell Carcinoma. ACS Applied Nano Materials 2024, 7, 7966-7977.

8. Guiqiang Zhang, Ning Wang, Yuan Ma, Shumei Zhai, To Ngai, Shilei Ni, Xingyi Jiang, Jianwei Jiao, Jiwei Cui, Metal coordination‐driven assembly of stimulator of interferon genes‐activating nanoparticles for tumor chemo‐immunotherapy. BMEMat 2024, 2, e12077.

9. Guiqiang Zhang, Xiao Fu, Haifeng Sun, Peiyu Zhang, Shumei Zhai, Jingcheng Hao, Jiwei Cui, Ming Hu, Poly(ethylene glycol)-Mediated Assembly of Vaccine Particles to Improve Stability and Immunogenicity. ACS Applied Materials & Interfaces 2021, 13, 13978.

10. Liyuan Wang#, Guiqiang Zhang#, Yang Sun, Zhuanchang Wu, Caiyue Ren, Zhaoying Zhang, Xueqi Peng,Yankun Zhang, Ying Zhao, Chunyang Li, Lifen Gao, Xiaohong Liang, Haifeng Sun, Jiwei Cui*, Chunhong Ma*. Enhanced Delivery of TLR7/8 Agonists by Metal-Organic Frameworks for Hepatitis B Virus Cure. ACS Applied Materials & Interfaces 2022, 14, 46176.

三、招生要求

学术型：偏向药学、化学、生物医学方向

专业型：偏向药学方向