一、个人简介

 张贵强，博士，副教授，山东省青年创新团队带头人。博士毕业于中国科学院过程工程研究所。主要研究兴趣：（1）功能性纳米粒子设计及其治疗炎性疾病和肿瘤的研究；（2）新型纳米疫苗设计及应用研究。以第一作者或通讯作者分别在ACS Nano、Journal of Controlled Release、BMEMat、Chemical Engineering Journal、Acta Biomaterialis等期刊上发表SCI期刊文章20余篇，授权专利5项。主持国家自然科学基金青年项目、中国博士后基金特别资助项目、山东省自然科学基金面上项目、山东省青年创新团队项目和山东中医药等项目，并参与了多项国家级和省部级课题研究。

二、代表论著

1. Xuechun Wang, Liu Liu, Jing Tian, Zhe Kong, Fei Lv, Jie Yan, Songyan Li, Zilin Ma, Dianhao Guo*, Yuelan Wang*, Changping Gu*, Guiqiang Zhang*. Carrier-Free Nano-Proteolysis Targeting Chimeras Enable Selective Protein Degradation and Enhance Photo-immunometabolic Therapy Against Lung Adenocarcinoma. ACS Nano 2026, doi.org/10.1021/acsnano.5c21154. (中科院一区TOP，IF=16.1)

2. Songyan Li, Yi Yue, Jintao Du, Wen Zhao, Binghan Liu, Zilin Ma, Xuechun Wang, Yuhua Wei*, Cong Song*, Guiqiang Zhang*. Carrier-Free Nanoreshapers Disrupt Cancer-Associated Fibroblast Barriers and Alleviate Immunosuppression for Synergistically Potentiated Immunotherapy. Journal of Controlled Release 2026, 393, 114835. (中科院一区TOP，IF=11.5)

3. Zilin Ma, Songyan Li, Wen Zhao, Binhan Liu, Xuechun Wang, Yilei Zhao, Yunxuan Song, Yueying Zhang*, Guiqiang Zhang*, Xiuying Duan*. Carrier-free PANoptosis Nanoinducers Synergize with Immunometabolic Reprogramming for Enhanced Immunotherapy. Journal of Controlled Release 2026, 392, 114732. (中科院一区TOP，IF=11.5)

4. Wenli Ning#, Yunhan Sun #, Mingyang Li #, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongong Liu, Fen Zhao*, Guiqiang Zhang*, Xiao Fu*. A nanoplatform that induces dual-amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy. BMEMat 2026, e70083. (中科院一区TOP，IF=15.5)

5. Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yizheng Yang, Yunxuan Song, Jianwei Jiao*, Xiuying Duan*, Guiqiang Zhang*, Nanomaterials-Mediated Glycolysis Rewriting to Potentiate Tumor Immunotherapy. BMEMat 2025, e70048. (中科院一区TOP，IF=15.5)

6. Jie Yan, Xuechun Wang, Yilei Zhao, Songyan Li, Zilin Ma, Yizheng Yang, Changping Gu*, Guiqiang Zhang*, Yuelan Wang*. Inflammation-Responsive Nanoparticles for Acute Lung Injury Treatment through Gas Therapy and Removal of Neutrophil Extracellular Traps. Chemical Engineering Journal 2025, 515, 163660. (中科院一区TOP，IF=13.2)

7. Songyan Li, Zilin Ma, Yilei Zhao, Jie Yan, Xuechun Wang, Wen Zhao, Jianwei Jiao*, Xiuying Duan*, Guiqiang Zhang*. Dual Metabolism-Disrupted Nanoparticles for Reprogramming the Immune Microenvironment to Potentiate Cuproptosis Immunotherapy. Materials Today Bio 2025, 32, 101799. (中科院一区TOP，IF=10.2)

8. Houyang Hu, Jie Yan, Haijun Zhu, Xuechun Wang, Yilei Zhao, Songyan Li, Zilin Ma, Fenglei Xu, Ming Xia, Jianwei Jiao*, Miaoqing Zhao*, Guiqiang Zhang*. Self-delivered sonodynamic nanomedicine for enhanced tumor immunotherapy by simultaneously reversing the immunosuppression and immune resistance. Chemical Engineering Journal 2024, 501, 157580. (中科院一区TOP，IF=13.2)

9. Yilei Zhao, Xiaonan Zhao, Xuechun Wang, Zilin Ma, Jie Yan, Songyan Li, Ning Wang, Jianwei Jiao*, Jiwei Cui*, Guiqiang Zhang*. Polyphenol-mediated assembly of Toll-like receptor 7/8 agonist nanoparticles for effective tumor immunotherapy. Acta Biomaterialia 2025, 193, 417-428. (中科院一区TOP，IF=9.6)

10. Guiqiang Zhang, Ning Wang, Yuan Ma, Shumei Zhai, To Ngai, Shilei Ni, Xingyi Jiang, Jianwei Jiao, Jiwei Cui, Metal coordination‐driven assembly of stimulator of interferon genes‐activating nanoparticles for tumor chemo‐immunotherapy. BMEMat 2024, 2, e12077. (中科院一区TOP，IF=15.5)

三、科研项目

1. 国家自然科学基金青年项目（21902088），2020.1-2022.12，26万元，主持

2. 中国博士后科学基金特别资助（2020T130071ZX），2020.6-2021.12，18万元，主持

3. 山东省自然科学基金面上项目（ZR2023MB081），2024.1-2026.12，10万元，主持

4. 山东省高等学校“青创团队计划”团队（2022KJ196），2023.1-2025.12，30万元，主持

5. 山东省中医药科技计划青年项目，2023.8-2025.7，2万元，主持

6. 山东第一医科大学骨干人才项目，2022.1-2026.12，200万元，主持

四、招生要求

学术型：药学、化学、生物医学方向

专业型：药学方向