一、 个人简介

石瑞，理学博士，副教授，山东省海外优青，山东省泰山学者青年专家，科创中心骨干人才。2023年11月博士毕业荷兰格罗宁根大学医学中心，同年赴香港浸会大学环境与生物分析国家重点实验室开展博士后研究工作。2025年10月加入山东第一医科大学。主要研究方向为:基于质谱的多组学技术开发及其在生命医学和环境健康研究中的应用，相关研究成果发表在Science Advances, ACS Nano, Environmental Science & Technology，Advanced Functional Materials等国际权威杂志。

二、 代表论著

1. R. Shi, P. Pan, R. Lv, C. Ma, E. Wu, R. Guo, Z. Zhao, H. Song, J. Zhou, Y. Liu, G. Xu, T. Hou, Z. Kang, J. Liu, High-throughput glycolytic inhibitor discovery targeting glioblastoma by graphite dots-assisted LDI mass spectrometry, Science Advances, 8 (2022) eabl4923.

2. R. Shi, Y. Chen, W. Wu, X. Diao, L. Chen, X. Liu, H. Wu, J. Wang, L. Zhu, Z. Cai, Mass Spectrometry-Based Spatial Multiomics Revealed Bioaccumulation Preference and Region-Specific Responses of PFOS in Mice Cardiac Tissue, Environmental Science & Technology, 59 (2025) 1957-1968.

3. R. Shi, X. Dai, W. Li, F. Lu, Y. Liu, H. Qu, H. Li, Q. Chen, H. Tian, E. Wu, Y. Wang, R. Zhou, S.T. Lee, Y. Lifshitz, Z. Kang, J. Liu, Hydroxyl-Group-Dominated Graphite Dots Reshape Laser Desorption/Ionization Mass Spectrometry for Small Biomolecular Analysis and Imaging, ACS Nano, 11 (2017) 9500-9513.

4. R. Shi, R. Lv, Z. Dong, Q. Cao, R. Wu, S. Liu, Y. Ren, Z. Liu, H.C. van der Mei, J. Liu, H.J. Busscher, Magnetically-targetable outer-membrane vesicles for sonodynamic eradication of antibiotic-tolerant bacteria in bacterial meningitis, Biomaterials, 302 (2023) 122320.

5. R. Shi, Z. Dong, C. Ma, R. Wu, R. Lv, S. Liu, Y. Ren, Z. Liu, H.C. van der Mei, H.J. Busscher, J. Liu, High-Yield, Magnetic Harvesting of Extracellular Outer-Membrane Vesicles from Escherichia coli, Small, 18 (2022) e2204350.

6. R. Shi, H. Li, E. Wu, L. Xiong, R. Lv, R. Guo, Y. Liu, G. Xu, Z. Kang, J. Liu, Simultaneous enzymatic activity modulation and rapid determination of enzyme kinetics by highly crystalline graphite dots, Nanoscale, 9 (2017) 8410-8417.

7. Q. Cao, X. Xiao, C. Tao, R. Shi*, R. Lv, R. Guo, X. Li, B. Sui, X. Liu, J. Liu*, Efficient clearance of periodontitis pathogens by S. gordonii membrane-coated H2O2 self-supplied nanocomposites in a “Jenga” style, Biomaterials Science, 11 (2023) 5680-5693.

8. R. Lv^#, R. Shi^#, E. Wu, C. Ma, R. Guo, J. Li, F. Ouyang, Q. Fang, L. Hu, C. Sun, Y. Liu, Z. Kang, J. Liu, Spatial-temporal profiling of antibiotic metabolites using graphite dots-assisted laser desorption ionization mass spectrometry, Talanta, 220 (2020) 121371.

9. E. Wu^#, K. Feng^#, R. Shi^#, R. Lv, F. Ouyang, S.S.C. Li, J. Zhong, J. Liu, Hybrid CuCoO-GO enables ultrasensitive detection of antibiotics with enhanced laser desorption/ionization at nano-interfaces, Chemical Science, 10 (2019) 257-267.

10. Y. Chen, R. Shi, J. Wang, C. Xie, Y. Song, R. Li, L. Wen, T. K. Lam, Z. Yang, and Z. Cai. Single-Cell 5 μm-Resolution Dual-Polarity MALDI-MS Imaging without Matrix Reapplication. Analytical Chemistry, 97 (2025), 17167-17174.

三、招生要求

学术型：偏向生信分析，分析化学，环境毒理学等方向

专业型：偏向公共卫生方向