一、个人简介
博士生导师。本科毕业于南开大学生命科学学院，博士及博士后阶段在中国科学院生物物理研究所完成，先后师从多位领域专家。曾任职于杭州师范大学、美国哥伦比亚大学医学中心，长期致力于人类长寿、衰老及衰老相关疾病机制研究，重点聚焦人类长寿相关功能基因组变异与调控机制、蛋白质稳态调控等方向。担任国家自然科学基金委项目评审专家、浙江省自然科学基金委基础公益计划项目评审专家。以第一/共同第一作者在Nature Cell Biology、Cell Research、Cell Death and Disease等期刊发表多篇高水平论文，获浙江省自然科学奖三等奖。主持国家自然科学基金面上项目、青年项目等多项国家及省部级项目；在干细胞衰老、蛋白质修饰与衰老调控等方向取得系统性创新成果，具有重要国际影响力。
二、代表论著
1. Chen, Lixiang; Liu, Qiang; Guan, Di*. The Aging Hematopoietic System: Mechanisms, Disorders, and Therapeutic Frontiers. Chinese Medical Journal. 2025 Sep 26;139(2):159-162.
2. Jiang Liu1, Di Guan1, Maogong Dong, Jingjing Yang, Haibin Wei, Qian Liang, Lizhi Song, Lu Xu, Junjie Bai, Cui Liu, Jian Mao, Qian Zhang, Junzhi Zhou, Xiaoying Wu, Miao Wang, Yu-Sheng Cong. Ufmylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination. Nat Cell Biol. 2020 Sep;22(9):1056-1063. (1共同第一作者)
3. Huize Pan1, Di Guan1, Xiaomeng Liu1 , Jingyi Li, Lixia Wang, Jun Wu, Junzhi Zhou, Weizhou Zhang, Ruotong Ren, Weiqi Zhang, Ying Li, Jiping Yang, Ying Hao, Tingting Yuan, Guohong Yuan, Hu Wang, Zhenyu Ju, Zhiyong Mao, Jian Li, Jing Qu, Fuchou Tang, and Guang-Hui Liu. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by transactivating NRF2. Cell Research. 2016 Feb;26(2):190-205 (1共同第一作者)
4. Di Guan1, Weiqi Zhang1, W Zhang, G-H Liu, and J C Izpisua Belmonte. Switching cell fate, ncRNAs coming to play, Cell Death and Disease. 2013 Jan 17;4(1):e464. (1共同第一作者)
5. Weiqi Zhang1, Di Guan1, Jing Qu, Weizhou Zhang, Guang-Hui Liu. Non-viral iPSC: a safe way for therapy? Protein Cell. 2012. 3(4):241-5. ( 1共同第一作者)
6. GUAN Di, LIU Chun-Ying, CHEN Chen, Yin Qin- Wei. miR-132 inhibits tumor metastasis. Progress in Biochemistry and Biophysics. 2012, 40(2):159-164
7. Mao J, Zhang Q, Wang Y, Zhuang Y, Xu L, Ma X, Guan D, Zhou J, Liu J, Wu X, Liang Q, Wang M, Cong YS. TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment. EMBO Rep. 2022 Apr 5;23(4):e52984.
8. Zhou J, Liang Q, Dong M, Ma X, Jin Y, Guan D, Liu J, Wang M, Cong YS. Optimized protocol to detect protein UFMylation in cells and in vitro via immunoblotting. STAR Protoc. 2022 Jan 6;3(1):101074.
9. Zhou Y, Ye X, Zhang C, Wang J, Guan Z, Yan J, Xu L, Wang K, Guan D, Liang Q, Mao J, Zhou J, Zhang Q, Wu X, Wang M, Cong YS, Liu J. Ufl1 deficiency causes kidney atrophy associated with disruption of endoplasmic reticulum homeostasis. J Genet Genomics. 2021 May 20;48(5):403-410.
10. Weiqi Zhang, Jingyi Li, Keiichiro Suzuki, Jing Qu, Ping Wang, Junzhi Zhou, Xiaomeng Liu, Ruotong Ren, Xiuling Xu, Alejandro Ocampo, Tingting Yuan, Jiping Yang, Ying Li, Liang Shi, Dee Guan, Huize Pan, Shunlei Duan, Zhichao Ding, Mo Li, Fei Yi, Ruijun Bai, Yayu Wang, Chang Chen, Fuquan Yang, Xiaoyu Li, Zimei Wang, Emi Aizawa, April Goebl, Rupa Devi Soligalla, Pradeep Reddy, Concepcion Rodriguez Esteban, Fuchou Tang, Guang-Hui Liu, and Juan Carlos Izpisua Belmonte. A Werner syndrome stem cell model unveils heterochromatin
alterations as a driver of human aging. Science. 2015,348(6239):1160-1163
三、招生要求
学术型：具备基础医学、临床医学、生物科学、生物技术、医学等相关专业背景；熟练掌握生物化学、分子生物学、细胞生物学核心理论与实验操作技能；具备良好的英文文献阅读与科研写作能力，具有较强科研思维与独立科研能力；对衰老机制与调控、人类长寿遗传机制、蛋白质稳态调控、干细胞生物学等研究领域具有浓厚兴趣；治学严谨、责任心强，学习能力突出，工作踏实主动，具有良好的团队协作精神。
