一、研究所介绍
模式动物研究水平决定了基础医学的发展水平，在山东第一医科大学大力发展模式动物，成为各级领导和广大科研工作者的一个共识。 依托于医学科技创新中心，基因工程与模式动物研究所主要以模式动物为研究工具，用以揭示人类疾病的发病机制，并利用模式动物筛选治疗疾病的创新药物。充分利用模式动物可以发表高水平的研究论文，提升基础医学的研究水平，并利用研究成果用来推动临床医学的发展。
本研究所在小鼠作为模式动物方面具有优势，我们拥有数位国内动物型领域的优秀人才。本研究所具有国家级人才两名，分别是长江学者1名，国家优青1名，山东省泰山学者1名，泰山学者青年人才4名。
二、研究领域
目前本研究所有四个研究方向，方向一为耳聋发生机制及治疗，利用小鼠为模型对耳聋发生的分子机制，以及相应的干预手段进行深入的研究。方向二主要围绕GH-IGF轴与疾病的关系，通过构建GH-IGF1轴关键基因敲除小鼠，研究其在代谢性疾病和肿瘤中的作用与机制。研究方向三为组织器官发育及衰老、肿瘤发生过程相关疾病的调控机制，并探索潜在的干预手段。 围绕发育相关信号通路异常与肿瘤发生发展的关系 ，研究衰老相关基因的功能及自身翻译后修饰调控。研究方向四为基于大规模人群队列和多组学技术开展疾病分子标志物筛查以及疾病检测技术的开发，利用人群队列开展心血管疾病和内分泌疾病的发病机制以及干预研究。
三、课题组
四、研究成果
（一）项目、论文、获奖等情况概述
获得国家级项目14项，国家重点研发课题2项，国自然面上项目4项，国自然青年项目8项。研究所自成立以来，发表多篇包括如Journal of Clinical Investigation, PNAS, Protein&Cell, Advanced Science , Molecular Therapy, Human Molecular Genetics, The FASEB Journal, Molecular Neurobiology, JARO, Fundamental Research等在内的多篇高水平研究论文。
（二）代表性成果
1. Hepatic steatosis aggravates atherosclerosis via small extracellular vesicle-mediated inhibition of cellular cholesterol efflux. J Hepatol. XuChen，Shen Chen，Juan Pang，Jinhe Xiao，Hongliang Xue，Wenhua Ling 2023 Sep 5:S0168-8278(23)05077-8. IF=25.7 一区
2. Peroxisome deficiency in cochlear hair cells causes hearing loss by deregulating BK channels Xiaolong Fu#*1, Peifeng Wan#1,2, Ling Lu4#, Yingcui Wan1, Ziyi Liu1, Guodong Hong1, Xiuli Bi1, Jing Zhou3, Ruifeng Qiao1, Siwei Guo2, Yu Xiao2, Bingzheng Wang1, Miao Chang1, Wen Li1,, Renjie Chai5 * ，Jiangang Gao1,2* ，Advanced Science 2023，DOI: 10.1002/advs.202300402 IF=17 一区
3. Deciphering early human pancreas development at the single-cell level. Zhuo Ma，Xiaofei Zhang，Wen Zhong，Hongyan Yi，Xiaowei Chen，Yinsuo Zhao，Yanlin Ma，Eli Song，Tao Xu. Nat Commun. 2023 Sep 2;14(1):5354. IF=16.6 一区
4. Higher mitochondrial DNA copy number is associated with metformin-induced weight loss. Wang, J., H. Liang, R. Huang, X. Weng, L. Zheng, Y. Wang, X. Zheng, Z. Gu, F. Chen, J. Shao, Z. Geng, E.R. Pearson, J. Weng, W. Yang, T. Xu, and K. Zhou. Commun Med (Lond), 2023. 3(1): p. 29. IF= 16.6 一区
5. Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis, Lingjun Tong#, Sitong Zhang#, Qiqi Liu, Chenyuan Huang, Haining Hao, Michelle Siying Tan, Xiaodong Yu, Charles Kang Liang Lou, Rong Huang, Zhe Zhang, Tongjie Liu, Pimin Gong, Cheng Han Ng, Mark Muthiah, Giorgia Pastorin, Matthias Gerhard Wacker, Xiaoyuan Chen, Gert Storm, Cheun Neng Lee, Lanwei Zhang, Huaxi Yi*, Jiong-Wei Wang*. Science Advances. 2023, 9,eade504. IF=13.6 一区
6. Deletion of hepatic growth hormone receptor (GHR) alters the mouse gut microbiota by affecting bile acid metabolism Zichao Yu, Yu Wang, Fang Zhang, Rui Ma, Xiaoyu Yang, Kun Yang, Ai Mi, Liyuan Ran*, Yingjie Wu* Gut Microbes 2023, 15: 2221098 IF=12.2 一区
7. Gss deficiency causes age-related fertility loss via ROS triggered ferroptosis in the testes of mice. Haixia Zhu, Yin Cheng, XianMei Wang, Xing Yang, Min Liu, Jun Liu, Shuqiao Liu, Hongxiang Wang, Aizhen Zhang, Runze Li, Chao Ye, Jiangang Gao* Fu Xiaolong*, Bin Wu*, Cell Death & Disease ，一区，IF=9
8. GATA zinc finger protein p66β promotes breast cancer cell migration by acting as a co-activator of Snail Xiuqun Zou#, Li Ma#, Yihong Zhang, Qun Zhang, Chu Xu, Dan Zhang, Yimin Chu, Jie Zhang, Mengying Li, Hui Zhang, Jiamin Wang, Chicheng Peng, Gang Wei, Yingjie Wu*, Zhaoyuan Ho*u, Hao Jia* Cell Death & Disease 2023, 14: 382 IF=9 一区
9. Xiaolong Fu, Peipei Li , Linqing Zhang ,Wenwen Liu，Yuan Zhang, Xiaoyang Sun， Renjie Chai *，Haibo Wang *，Jiangang Gao *. Activation of Rictor/mTORC2 signaling acts as a new pivotal strategy to protect against sensorineural hearing loss PNAS 2022, IF 11.5 , 一区
10. Peipei Li#, Ziyi Liu#, Jinpeng Wang#, Xiuli Bi, Yu Xiao, Ruifeng Qiao, Xuanchen Zhou, Siwei Guo, Peifeng Wan, Miao Chang, Guodong Hong, Zhangsuo Liu, Xia Ming, Jiangang Gao*, Xiaolong Fu* Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice The FASEB Journal 2022.06; 36(6). IF 5.19,一区
11. Min Liu, Shuangyuan Liu, Chenyang Song, Haixia Zhu, Bin Wu, Aizhen Zhang, Hui Zhao, Zongzhuang Wen*, Jiangang Gao*, Pre-meiotic deletion of PEX5 causes spermatogenesis failure and infertility in mice, Cell Proliferation, 2022:26;e13365 IF=8.755 一区
12. Junling Yin, Ling Huang, Luling Wu, Jiangfeng Li, Tony D. James, Weiying, Small molecule based fluorescent chemosensors for imaging the microenvironment within specific cellular regions；Chem Soc Rev; 1区, IF：54.5
六、联系方式
联系人：高建刚
联系方式：jggao@sdfmu.edu.cn
